3 - O - 甲基多巴与帕金森病的运动波动
3-O-methyldopa and motor fluctuations in Parkinson's disease.
作者信息
Fabbrini G, Juncos J L, Mouradian M M, Serrati C, Chase T N
出版信息
Neurology. 1987 May;37(5):856-9. doi: 10.1212/wnl.37.5.856.
PMID:3574690
Abstract
High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of disease. It appears unlikely that plasma OMD accumulation contributes to the pathogenesis of wearing-off or on-off responses.
摘要
在长期接受左旋多巴治疗的帕金森病患者中发现血浆3 - O - 甲基多巴（OMD）水平较高，尤其是那些有开关现象的患者。然而，在疾病的任何阶段，左旋多巴代谢产物的循环水平与运动反应波动的存在之间均未建立关联。血浆OMD的蓄积似乎不太可能导致疗效减退或开关反应的发病机制。
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