Department of Neurosurgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China.
Biomed Res Int. 2022 Jun 14;2022:4931210. doi: 10.1155/2022/4931210. eCollection 2022.
The main aim of this study was to investigate the therapeutic effect of endovascular interventional therapy on cerebral venous sinus thrombosis (CVST). 137 patients with CVST were included, 92 patients were treated with interventional therapy, and 45 patients were treated with conventional anticoagulant therapy. Through endovascular therapy (EVT) combined with therapy, the patients were treated with EVT in combination with conventional anticoagulant therapy, and the prognosis of the two groups of patients was evaluated. The results showed that 26 patients were complicated with female-specific infections in the combined EVT group, and 7 patients had female-specific infections in the simple anticoagulant therapy (LMWH) group. In terms of central nervous system infections, the EVT group was significantly lower than the LMWH group, < 0.001, and the difference was statistically significant. There were 2 cases of EVT involving the inferior sagittal sinus and 12 cases of LMWH involving the inferior sagittal sinus, < 0.001, and the difference had statistical significance. Through the RANKIN scale (mRS) score, it was classified as complete recovery and good prognosis (dependent variable). The patients receiving EVT with good prognosis (96.7%) were more than those receiving simple anticoagulant therapy (84.4%), and 78.3% were completely recovered after EVT, and 77.5% were completely recovered after anticoagulant therapy. Therefore, it can be concluded that gender, malignant tumors, thrombosis, and sinuses are all risk factors affecting the prognosis of patients; both endovascular interventional therapy and anticoagulant therapy can significantly improve the prognosis of patients.
本研究的主要目的是探讨血管内介入治疗对脑静脉窦血栓形成(CVST)的治疗效果。共纳入 137 例 CVST 患者,其中 92 例行介入治疗,45 例行常规抗凝治疗。通过血管内治疗(EVT)联合治疗,将 EVT 与常规抗凝治疗联合治疗,评价两组患者的预后。结果显示,联合 EVT 组中有 26 例患者并发女性特有的感染,单纯抗凝治疗(LMWH)组中有 7 例患者发生女性特有的感染。在中枢神经系统感染方面,EVT 组明显低于 LMWH 组,<0.001,差异有统计学意义。EVT 组有 2 例累及下矢状窦,LMWH 组有 12 例累及下矢状窦,<0.001,差异有统计学意义。通过 RANKIN 量表(mRS)评分,将其分为完全恢复和预后良好(因变量)。接受 EVT 治疗的预后良好(96.7%)的患者多于接受单纯抗凝治疗(84.4%)的患者,EVT 后完全恢复的患者为 78.3%,抗凝治疗后完全恢复的患者为 77.5%。因此,可以得出结论,性别、恶性肿瘤、血栓形成和窦是影响患者预后的危险因素;血管内介入治疗和抗凝治疗均可显著改善患者的预后。