Cummins J T, von Euler G, Fuxe K, Ogren S O, Agnati L F
Neurosci Lett. 1987 Mar 31;75(2):152-6. doi: 10.1016/0304-3940(87)90289-8.
The effects of chronic oral (2 X 10 mumol/kg, twice daily for 14 days) imipramine treatment on (+)2-[125I]-iodolysergic acid, diethylamide (125I-LSD) and 125I-neuropeptide Y (125I-NPY) receptor binding were examined in rat cerebral cortex by quantitative receptor autoradiography. A 35% reduction of 125I-LSD binding was observed in layer IV, both in the frontal and occipital cortex, while there was no significant change in 125I-NPY binding. The observed decrease in 125I-LSD binding is probably due to a reduction in the density of 5-hydroxytryptamine (5-HT) receptors of the 5-HT2 type. This reduction may represent a disturbance in the 5-HT synapses, regulating the transmission of the specific afferents innervating layer IV of the cerebral cortex.
通过定量受体放射自显影术，研究了慢性口服丙咪嗪（2×10 μmol/kg，每日两次，共14天）对大鼠大脑皮层中（+）2-[¹²⁵I]-碘麦角酰二乙胺（¹²⁵I-LSD）和¹²⁵I-神经肽Y（¹²⁵I-NPY）受体结合的影响。在额叶和枕叶皮层的IV层观察到¹²⁵I-LSD结合减少了35%，而¹²⁵I-NPY结合没有显著变化。观察到的¹²⁵I-LSD结合减少可能是由于5-羟色胺（5-HT）2型受体密度降低所致。这种减少可能代表5-HT突触的紊乱，该突触调节支配大脑皮层IV层的特定传入神经的传递。
