Department of Otolaryngology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing 210014, China.
Department of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Comput Intell Neurosci. 2022 Jun 14;2022:6935758. doi: 10.1155/2022/6935758. eCollection 2022.
The prevalence of allergic rhinitis has exhibited an upward trend, and diabetes is a common endocrine metabolic disorder. Treatment of allergic rhinitis complicated with diabetes has been marginally explored. This study aimed to observe the effect of rupatadine fumarate combined with acupoint application in the treatment of allergic rhinitis complicated with diabetes and its effect on serum IgE levels. Totally 80 patients with allergic rhinitis complicated with diabetes admitted to our hospital from December 2019 to December 2020 were recruited and assigned to receive either rupatadine fumarate (control group) or rupatadine fumarate plus acupoint application (research group). The clinical observation indexes of the two groups of patients before and after treatment were analyzed, and the clinical efficacy of the two groups was evaluated. Rupatadine fumarate plus acupoint application was associated with a significantly higher efficacy (23 cases of markedly effective, 14 cases of effective, and 3 cases of ineffective) versus rupatadine fumarate alone (14 cases of markedly effective, 16 cases of effective, and 10 cases of ineffective) ( = 4.501, = 0.034). The immunoglobulin E (IgE) and nasal mucosal eosinophils (EOS) levels of the two groups of patients after treatment decreased significantly, and the research group had lower results ( < 0.05). Patients in the research group showed significantly lower syndrome scores than those in the control group ( < 0.05). Rupatadine fumarate plus acupoint application resulted in significantly lower physical sign scores and interleukin-4 (IL-4) levels and higher levels of interferon-gamma (INF-) versus rupatadine fumarate alone ( < 0.05). The two groups showed a similar incidence of adverse events ( > 0.05). Rupatadine fumarate plus acupoint application may offer a viable alternative for the treatment of allergic rhinitis as it alleviates the clinical symptoms, improves the treatment efficiency, and enhances the anti-allergic effect of the drug, with a high safety profile.
变应性鼻炎的患病率呈上升趋势，糖尿病是常见的内分泌代谢紊乱疾病。变应性鼻炎合并糖尿病的治疗方法略有探索。本研究旨在观察富马酸卢帕他定联合穴位贴敷治疗变应性鼻炎合并糖尿病的效果及其对血清 IgE 水平的影响。
选取 2019 年 12 月至 2020 年 12 月我院收治的 80 例变应性鼻炎合并糖尿病患者，随机分为富马酸卢帕他定组（对照组）和富马酸卢帕他定联合穴位贴敷组（研究组）。分析两组患者治疗前后的临床观察指标，评价两组的临床疗效。
富马酸卢帕他定联合穴位贴敷的疗效明显高于富马酸卢帕他定（显效 23 例，有效 14 例，无效 3 例）（ = 4.501， = 0.034）。两组患者治疗后免疫球蛋白 E（IgE）和鼻黏膜嗜酸性粒细胞（EOS）水平均明显下降，研究组下降更明显（ < 0.05）。研究组患者的证候评分明显低于对照组（ < 0.05）。与富马酸卢帕他定组相比，富马酸卢帕他定联合穴位贴敷组的体征评分、白细胞介素-4（IL-4）水平显著降低，干扰素-γ（INF-γ）水平显著升高（ < 0.05）。两组不良反应发生率比较差异无统计学意义（ > 0.05）。
富马酸卢帕他定联合穴位贴敷治疗变应性鼻炎可缓解临床症状，提高治疗效率，增强药物的抗过敏作用，且安全性高。
