Crabtree Judy S
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Front Oncol. 2022 Jun 7;12:901435. doi: 10.3389/fonc.2022.901435. eCollection 2022.
Gastroenteropancreatic neuroendocrine neoplasms are a rare, diverse group of neuroendocrine tumors that form in the pancreatic and gastrointestinal tract, and often present with side effects due to hormone hypersecretion. The pathogenesis of these tumors is known to be linked to several genetic disorders, but sporadic tumors occur due to dysregulation of additional genes that regulate proliferation and metastasis, but also the epigenome. Epigenetic regulation in these tumors includes DNA methylation, chromatin remodeling and regulation by noncoding RNAs. Several large studies demonstrate the identification of epigenetic signatures that may serve as biomarkers, and others identify innovative, epigenetics-based targets that utilize both pharmacological and theranostic approaches towards the development of new treatment approaches.
胃肠胰神经内分泌肿瘤是一组罕见且多样的神经内分泌肿瘤，形成于胰腺和胃肠道，常因激素分泌过多而出现副作用。已知这些肿瘤的发病机制与多种基因紊乱有关，但散发性肿瘤是由于调控增殖、转移以及表观基因组的其他基因失调所致。这些肿瘤中的表观遗传调控包括DNA甲基化、染色质重塑以及非编码RNA的调控。多项大型研究表明，已鉴定出可能作为生物标志物的表观遗传特征，其他研究则确定了基于表观遗传学的创新靶点，这些靶点利用药理学和诊疗方法来开发新的治疗方法。
