可乐定过量致心力衰竭一例

Clonidine Overdose as an Unusual Cause of Heart Failure.

机构信息

Kern Medical Center, Bakersfield, CA, USA.

University of California, San Francisco, Fresno, USA.

出版信息

J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221106856. doi: 10.1177/23247096221106856.

DOI:10.1177/23247096221106856

PMID:35748424

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9235301/

Abstract

Clonidine is used as an antihypertensive medication due to its effect on decreasing peripheral vascular resistance and therefore lowering blood pressure. Alpha antagonism in the medulla and the posterior hypothalamus causing a reduction in sympathetic activation allows for clonidine to be used as an effective off-label treatment for attention-deficit/hyperactivity disorder (ADHD). This is a case of a 28-year-old female with hypertension, ADHD, and depression who developed acute heart failure with significant troponemia after ingesting 30 pills of clonidine. We illustrate the possible rare diagnosis of systolic heart failure and coronary vasospasm secondary to clonidine overdose.

摘要

可乐定被用作降压药物，因为它可以降低外周血管阻力，从而降低血压。在延髓和下丘脑后区的α拮抗作用导致交感神经激活减少，这使得可乐定可被有效用作治疗注意力缺陷多动障碍（ADHD）的标签外药物。这是一例 28 岁女性高血压、ADHD 和抑郁症患者，在摄入 30 片可乐定后出现急性心力衰竭和显著肌钙蛋白血症。我们阐述了可能的罕见诊断，即可乐定过量导致的收缩性心力衰竭和冠状动脉痉挛。