Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
Center of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
J Infect Dis. 2022 Sep 4;226(4):673-677. doi: 10.1093/infdis/jiac235.
The risk of a severe course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults with Down syndrome is increased, resulting in an up to 10-fold increase in mortality, in particular in those >40 years of age. After primary SARS-CoV-2 vaccination, the higher risks remain. In this prospective observational cohort study, SARS-CoV-2 spike S1-specific antibody responses after routine SARS-CoV-2 vaccination (BNT162b2, messenger RNA [mRNA]-1273, or ChAdOx1) in adults with Down syndrome and healthy controls were compared. Adults with Down syndrome showed lower antibody concentrations after 2 mRNA vaccinations or after 2 ChAdOx1 vaccinations. After 2 mRNA vaccinations, lower antibody concentrations were seen with increasing age.
NCT05145348.
唐氏综合征成人感染严重急性呼吸综合征冠状病毒 2 （SARS-CoV-2）的严重病程风险增加，死亡率上升了约 10 倍，特别是年龄大于 40 岁的患者。初次 SARS-CoV-2 疫苗接种后，这些较高的风险仍然存在。在这项前瞻性观察队列研究中，比较了唐氏综合征成人和健康对照者在常规 SARS-CoV-2 疫苗（BNT162b2、信使 RNA [mRNA]-1273 或 ChAdOx1）接种后的 SARS-CoV-2 刺突 S1 特异性抗体反应。2 种 mRNA 疫苗接种或 2 种 ChAdOx1 疫苗接种后，唐氏综合征成人的抗体浓度较低。接受 2 次 mRNA 疫苗接种后，抗体浓度随年龄的增加而降低。
NCT05145348。
