Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven 5600 MB, the Netherlands; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, the Netherlands.
Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven 5600 MB, the Netherlands; Department of Chemical Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia.
Curr Opin Chem Biol. 2022 Aug;69:102171. doi: 10.1016/j.cbpa.2022.102171. Epub 2022 Jun 21.
Supramolecular glycopolymers exhibiting inherent dynamicity, tunability, and adaptivity allow us to arrive at a deeper understanding of multivalent carbohydrate-carbohydrate interactions and carbohydrate-protein interactions, both being essential to key biological events. The impacts of the carbohydrate segments in these supramolecular glycopolymers towards their structure, dynamics, and function as biomaterials are addressed in this minireview. Bottlenecks and challenges are discussed, and we speculate about possible future directions.
超分子糖聚合物具有内在的动态性、可调性和适应性，使我们能够更深入地了解多价糖-糖相互作用和糖-蛋白相互作用，这两者对于关键的生物事件都是至关重要的。本综述讨论了这些超分子糖聚合物中糖链段对其作为生物材料的结构、动态和功能的影响。讨论了瓶颈和挑战，并对可能的未来方向进行了推测。
