Wang X L, Zhai J, Zou Y X
Department of Infection,Tianjin Children's Hospital (Children's Hospital of Tianjin University) Machang Campus, Tianjin 300074, China.
Zhonghua Er Ke Za Zhi. 2022 Jun 15;60(7):671-675. doi: 10.3760/cma.j.cn112140-20220506-00417.
To investigate the clinical characteristics and vaccination status of SARS-CoV-2 Omicron variant infected children. A total of 105 children infected with Omicron variant admitted to Tianjin Haihe Hospital (designated referral hospital for SARS-CoV-2 infection in Tianjin) from January 8, 2022 to February 3 were included for a retrospective study. The cases were divided into pneumonia group and non-pneumonia group according to chest imaging. Based on the doses of inactivated SARS-CoV-2 vaccine, the children who completed SARS-CoV-2 antibody test within 3 days after hospitalization were divided into 2 dose group and<2 dose group.Rank sum test and Chi-square test were used for the comparison between the groups. The age of these 105 children was 10 (8, 11) years on admission, 53 children were males and 52 were females. Eighty-seven cases (82.9%) had mild symptoms, 13 cases (12.4%) had common symptoms and 5 cases (4.8%) were asymptomatic. Ninety-one cases (86.7%) completed 2 doses vaccination. The clinical symptoms were characterized by cough (74 cases, 70.5%), fever (58 cases, 55.2%), sore or dry throat (34 cases, 32.4%), nasal congestion (28 cases, 26.7%), rhinorrhea (23 cases, 21.9%). None of the children received antivirals, steroids, immunosuppressant or oxygen therapy. Seventy-six cases(72.4%) received traditional Chinese medicine treatment. The pneumonia group had a higher rate of positive SARS-CoV-2 IgG within 1 day after admission (13/13 87.0% (80/92), χ=42.81, 0.001) than the non-pneumonia group. Among the 62 children who had serial SARS-CoV-2 antibody tests within 3 days after hospitalization, Compared to the<2 dose group, the 2 dose group had a higher rate of nucleic acid conversion within 16 days after onset and a higher rate of positive SARS-CoV-2 IgG 1 day after admission and 3 days after hospitalization (96.4% (54/56) . 4/6, 100.0% (56/56) 2/6, 100.0% (56/56) 3/6, all 0.05). Most children infected with Omicron variant have mild symptoms, mainly respiratory infection symptoms. The proportion of SARS-CoV-2 antibody IgG positive in children who have received 2 doses of inactivated SARS-CoV-2 vaccines is higher,and the time of whose nucleic acid conversion may be shortened.
调查新型冠状病毒奥密克戎变异株感染儿童的临床特征及疫苗接种情况。纳入2022年1月8日至2月3日在天津市海河医院（天津市新型冠状病毒感染指定定点医院）收治的105例奥密克戎变异株感染儿童进行回顾性研究。根据胸部影像学将病例分为肺炎组和非肺炎组。根据新型冠状病毒灭活疫苗接种剂次，将住院后3天内完成新型冠状病毒抗体检测的儿童分为2剂组和<2剂组。组间比较采用秩和检验和卡方检验。这105例儿童入院时年龄为10（8，11）岁，男53例，女52例。87例（82.9%）症状轻微，13例（12.4%）症状普通，5例（4.8%）无症状。91例（86.7%）完成2剂疫苗接种。临床症状以咳嗽（74例，70.5%）、发热（58例，55.2%）、咽痛或咽干（34例，32.4%）、鼻塞（28例，26.7%）、流涕（23例，21.9%）为主。所有儿童均未接受抗病毒药物、糖皮质激素、免疫抑制剂治疗及吸氧治疗。76例（72.4%）接受了中医药治疗。肺炎组入院后1天内新型冠状病毒IgG阳性率高于非肺炎组（13/13对87.0%（80/92），χ²=42.81，P<0.001）。在住院后3天内进行系列新型冠状病毒抗体检测的62例儿童中，与<2剂组相比，2剂组发病后16天内核酸转阴率更高，入院后1天及住院后3天新型冠状病毒IgG阳性率更高（96.4%（54/56）对4/6，100.0%（56/56）对2/6，100.0%（56/56）对3/6，均P<0.05）。多数奥密克戎变异株感染儿童症状轻微，主要为呼吸道感染症状。接种2剂新型冠状病毒灭活疫苗的儿童新型冠状病毒抗体IgG阳性比例更高，且核酸转阴时间可能缩短。
