Bean A J, Elgin R J, Cooper D M, Martin G E
Peptides. 1987 Jan-Feb;8(1):39-44. doi: 10.1016/0196-9781(87)90162-8.
Behavioral effects of cyclo (Leu-Gly) (cLG), administered either acutely or chronically, were assessed in combination with haloperidol in the rat. cLG administered chronically, produced a significant reduction in the increase in apomorphine-induced stereotypy produced by chronic haloperidol infusion. On the other hand, the same dose of cLG which reduced this induction of dopamine receptor supersensitivity due to chronic haloperidol treatment, failed to produce a change in the potency of haloperidol in blocking conditioned avoidance responding in the rat. Furthermore, degeneration-induced supersensitivity of dopamine neurons, produced by unilateral destruction of the nigrostriatal pathway, was not reduced by acute or chronic treatment with cLG as measured by apomorphine-induced rotation. These data suggest that cLG may decrease motor system side effects thought to be caused by chronic antipsychotic administration without affecting the therapeutic efficacy of the antipsychotic agent.
在大鼠中，评估了急性或慢性给予环（亮氨酸 - 甘氨酸）（cLG）与氟哌啶醇联合使用时的行为效应。长期给予cLG可显著降低慢性输注氟哌啶醇所产生的阿扑吗啡诱导的刻板行为增加。另一方面，相同剂量的cLG虽然减少了因慢性氟哌啶醇治疗引起的多巴胺受体超敏反应诱导，但未能改变氟哌啶醇阻断大鼠条件性回避反应的效力。此外，通过阿扑吗啡诱导的旋转测量，黑质纹状体通路单侧破坏所产生的多巴胺神经元变性诱导超敏反应，并未因急性或慢性cLG治疗而降低。这些数据表明，cLG可能会减少被认为是由慢性抗精神病药物给药引起的运动系统副作用，而不影响抗精神病药物的治疗效果。
