不对称1,4 - 二取代哌嗪的合成及其精神和心血管作用。第一部分。
Synthesis of asymmetric 1,4-disubstituted piperazines and their psychotropic and cardiovascular actions. Part I.
作者信息
Korzycka L, Białasiewicz W, Szadowska A, Polakowski P, Graczyk J
出版信息
Pol J Pharmacol Pharm. 1986 Sep-Dec;38(5-6):535-43.
PMID:3575169
Abstract
New asymmetric piperazines 1-6 were obtained by condensation of 1-acylpiperazines with 1,2-epoxy-3-chloropropane, 1,2-epoxypropane, arylacid chlorides and secondary amines. The compounds displayed a biological activity: they depressed the central nervous system, altered the blood pressure, and one of them increased the coronary flow.
摘要
通过1-酰基哌嗪与1,2-环氧-3-氯丙烷、1,2-环氧丙烷、芳酰氯和仲胺缩合，得到了新的不对称哌嗪1-6。这些化合物具有生物活性：它们会抑制中枢神经系统、改变血压，其中一种还会增加冠脉血流量。
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