作为潜在心血管药物的N-芳基-N-氨基哌嗪衍生物。
Derivatives of n-aryl-N-amino piperazines as potential cardiovascular agents.
作者信息
Dubey M, Verma V K, Sharma M, Shanker K, Sinha J N, Bhargava K P, Kishor K
出版信息
Pol J Pharmacol Pharm. 1981 Oct;33(3):349-57.
PMID:7322947
Abstract
24 new substituted piperazino guanidines and 34 substituted benzylideno- or benzylamino-4-phenyl piperazines were synthesized and evaluated for their cardiovascular activity. Several compounds of the above two series exhibited vasopressor or vasodepressor activity without modifying the carotid occlusion (CO) and noradrenaline (NA) induced pressor responses.
摘要
合成了24种新的取代哌嗪胍和34种取代亚苄基或苄氨基-4-苯基哌嗪，并对其心血管活性进行了评估。上述两个系列的几种化合物表现出血管升压或血管降压活性，而不改变颈动脉闭塞（CO）和去甲肾上腺素（NA）诱导的升压反应。
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