应用预防性光疗预防 RhD 新生儿溶血病：转诊服务中的应用。
Use of prophylactic phototherapy for RhD neonatal disease in a referral service.
机构信息
Fundação Oswaldo Cruz (FIOCRUZ), Instituto Fernandes Figueira, Departamento de Neonatologia, Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz (FIOCRUZ), Instituto Fernandes Figueira, Pós-graduação em Pesquisa Clínica Aplicada, Rio de Janeiro, RJ, Brazil.
出版信息
J Pediatr (Rio J). 2023 Jan-Feb;99(1):53-58. doi: 10.1016/j.jped.2022.04.004. Epub 2022 Jun 23.
OBJECTIVE
This study aimed to describe the effect of prophylactic phototherapy in the treatment of infants with Neonatal Hemolytic Disease.
METHOD
A retrospective cohort study was carried out with 199 RhD-positive infants, born to RhD-negative mothers, alloimmunized for RhD antigen, between January 2009 and December 2018.
RESULTS
The incidence of exchange transfusions in the study population was 9.5%, with a mean maximum bilirubin value of 11.3 mg % (± 4.3mg %). Bilirubin's maximum peak was achieved with a mean of 119.2 life hours (± 70.6h).
CONCLUSION
The low incidence of exchange transfusion, the extended maximum bilirubin peak for later ages, and the low mean of the maximum bilirubin values may indicate a positive effect of prophylactic phototherapy in the treatment of this disease. Further studies must be carried out to confirm these findings.
目的
本研究旨在描述预防性光疗对新生儿溶血病患儿的治疗效果。
方法
采用回顾性队列研究，纳入 2009 年 1 月至 2018 年 12 月间 199 例 RhD 阳性、RhD 阴性母亲所生、因 RhD 抗原同种免疫的 RhD 阳性婴儿。
结果
研究人群中换血治疗的发生率为 9.5%，平均最大胆红素值为 11.3mg%（±4.3mg%）。胆红素的最大峰值出现在平均 119.2 个生命小时（±70.6h）。
结论
换血治疗的发生率较低，最大胆红素峰值出现的时间较晚，最大胆红素平均值较低，这可能表明预防性光疗对该疾病的治疗有积极作用。需要进一步开展研究以证实这些发现。
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