Klindt J, Jenkins T G, Ford J J
Proc Soc Exp Biol Med. 1987 Jun;185(2):201-5. doi: 10.3181/00379727-185-42535.
Growth and secretion of growth hormone (GH) and prolactin (PRL) in ewe lambs exposed to androgen during fetal development were investigated. Testosterone cypionate was administered to the pregnant dams from approximately Days 28 to 84 of gestation. Ewe lambs from dams that received androgen exhibited masculinized external genitalia and some masculine behavioral characteristics. Intact androgenized ewe lambs grew faster (P less than 0.05) and were more efficient in conversion of food to body gain (P less than 0.05) than ewe lambs born to untreated dams over the period from 70 to 224 days of age. One-half of the ewe lambs in each group was ovariectomized at 58 days of age. Ovariectomy had no effect on subsequent growth or efficiency of growth in the control ewe lambs. However, ovariectomy of androgenized ewe lambs abolished the observed stimulated rate of growth and decreased the improvement in efficiency of food conversion. Blood samples were collected from the lambs at 85 and 136 days of age at 15-min intervals for 8 hr to determine parameters of GH and PRL secretion. Prenatal androgen exposure had no effect on any parameter of GH or PRL secretion. These data indicate that prenatal androgen exposure altered differentiation of growth potential in ewe lambs, but the growth response was not mediated through dramatic changes in secretion of adenohypophysial somatotropic hormones, GH and PRL.
研究了在胎儿发育期间暴露于雄激素的母羊羔中生长激素（GH）和催乳素（PRL）的生长及分泌情况。从妊娠约28天至84天给怀孕母羊注射环戊丙酸睾酮。来自接受雄激素处理母羊的母羊羔表现出雄性化的外生殖器和一些雄性行为特征。在70至224日龄期间，完整的雄激素化母羊羔比未处理母羊所生的母羊羔生长更快（P<0.05），并且在食物转化为体重增加方面更有效率（P<0.05）。每组中的一半母羊羔在58日龄时进行卵巢切除。卵巢切除对对照母羊羔随后的生长或生长效率没有影响。然而，雄激素化母羊羔的卵巢切除消除了观察到的生长刺激率，并降低了食物转化效率的改善。在85和136日龄时，每隔15分钟从羊羔采集一次血样，持续8小时，以测定GH和PRL分泌参数。产前雄激素暴露对GH或PRL分泌的任何参数均无影响。这些数据表明，产前雄激素暴露改变了母羊羔生长潜力的分化，但生长反应并非通过腺垂体生长激素（GH和PRL）分泌的显著变化介导。
