Jhanwar-Uniyal M, Darwish M, Levin B E, Leibowitz S F
Pharmacol Biochem Behav. 1987 Feb;26(2):271-5. doi: 10.1016/0091-3057(87)90117-1.
The present study determined the levels and turnover of norepinephrine (NE), epinephrine (EPI) and dopamine (DA) in discrete brain areas of rats after 48 hr food deprivation. The steady-state levels of NE, EPI and DA in saline-treated food-deprived rats, relative to satiated rats, remained basically unchanged. However, 48 hr deprivation caused a site-selective potentiation, specifically in the hypothalamic paraventricular nucleus, in the depletion of NE after alpha-methyl-p-tyrosine injection (IP, 200 mg/kg), indicating an increase in NE turnover. While changes in EPI turnover could not be demonstrated, an apparent increase in DA turnover was detected in the perifornical lateral hypothalamus and anterior hypothalamic nucleus after deprivation, while decreased DA turnover was seen in the hypothalamic dorsomedial nucleus and caudate nucleus. These results may reflect specific functions of hypothalamic catecholamines in control of food intake.
本研究测定了禁食48小时后大鼠离散脑区中去甲肾上腺素（NE）、肾上腺素（EPI）和多巴胺（DA）的水平及周转率。相对于饱食大鼠，盐水处理的禁食大鼠中NE、EPI和DA的稳态水平基本保持不变。然而，48小时禁食导致α-甲基-对-酪氨酸注射（腹腔注射，200mg/kg）后NE耗竭出现位点选择性增强，具体表现为下丘脑室旁核，这表明NE周转率增加。虽然未证实EPI周转率的变化，但在禁食后的穹窿周外侧下丘脑和下丘脑前核中检测到DA周转率明显增加，而在下丘脑背内侧核和尾状核中则观察到DA周转率下降。这些结果可能反映了下丘脑儿茶酚胺在控制食物摄入方面的特定功能。
