School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK; School of Pharmacy, Universita di Roma Tor Vergata, Rome, Italy.
Int J Pharm. 2022 Aug 25;624:121947. doi: 10.1016/j.ijpharm.2022.121947. Epub 2022 Jun 23.
Although natural sesame oil has been shown to facilitate the lymphatic delivery and oral bioavailability of the highly lipophilic drug cannabidiol (CBD), considerable variability remains an unresolved challenge. Vegetable oils differ substantially in composition, which could lead to differences in promotion of intestinal lymphatic transport of lipophilic drugs. Therefore, the differences in composition of sesame, sunflower, peanut, soybean, olive and coconut oils and their corresponding role as vehicles in promoting CBD lymphatic targeting and bioavailability were investigated in this study. The comparative analysis suggests that the fatty acids profile of vegetable oils is overall similar to the fatty acids profile in the corresponding chylomicrons in rat lymph. However, arachidonic acid (C20:4), was introduced to chylomicrons from endogenous nondietary sources. Overall, fatty acid composition of natural vegetable oils vehicles affected the intestinal lymphatic transport and bioavailability of CBD following oral administration in this work. Olive oil led to the highest concentration of CBD in the lymphatic system and in the systemic circulation in comparison to the other natural vegetable oils following oral administration in rats.
尽管已证实天然芝麻油可促进高度亲脂性药物大麻二酚（CBD）的淋巴传递和口服生物利用度，但仍存在相当大的变异性，这是一个尚未解决的挑战。植物油在组成上有很大的差异，这可能导致促进亲脂性药物肠内淋巴转运的差异。因此，本研究考察了芝麻油、葵花籽油、花生油、大豆油、橄榄油和椰子油在组成上的差异及其作为载体促进 CBD 淋巴靶向和生物利用度的相应作用。比较分析表明，植物油的脂肪酸谱与大鼠淋巴中的乳糜微粒中的脂肪酸谱总体相似。然而，花生四烯酸（C20:4）是从内源性非饮食来源引入乳糜微粒的。总的来说，天然植物油载体的脂肪酸组成影响了 CBD 经口服给药后的肠道淋巴转运和生物利用度。与其他天然植物油相比，橄榄油在口服给予大鼠后，可使 CBD 在淋巴系统和全身循环中的浓度最高。
