Caffry E W, Kissileff H R, Thornton J C
Pharmacol Biochem Behav. 1987 Feb;26(2):321-5. doi: 10.1016/0091-3057(87)90125-0.
Single 37.5 mg doses of phenylpropanolamine (PPA) were given on each of two separate, nonconsecutive days to each of twelve nonobese women. PPA's effects on reported appetite and food intake were compared to those of a placebo also given on two nonconsecutive days. To control for possible effects on appetitive behavior of knowledge about the drug's putative role as an appetite suppressant, the subjects were told that PPA was a nasal decongestant which was expected to affect their sensitivity to flavors. Hunger rating before eating was significantly lower on trials after PPA than on trials after placebo (carry-over effect), but the direct effect of PPA on hunger was not significant. Although food intake was 26 g less under the PPA condition (407 g) than under placebo (433 g), this difference was not significant. However, because of insufficient power, the null hypothesis could not be accepted. The true effect of PPA on intake remains inconclusive. Either more subjects must be tested at this dose or the effect must be made larger by changing the dose, in order to obtain conclusive results.
在两个不连续的日子里，分别给12名非肥胖女性每人单次服用37.5毫克苯丙醇胺（PPA）。将PPA对所报告的食欲和食物摄入量的影响与同样在两个不连续日子里服用的安慰剂的影响进行比较。为了控制对药物作为食欲抑制剂的假定作用的了解可能对食欲行为产生的影响，受试者被告知PPA是一种鼻减充血剂，预计会影响她们对味道的敏感度。服用PPA后的试验中，进食前的饥饿评分显著低于服用安慰剂后的试验（残留效应），但PPA对饥饿的直接影响并不显著。尽管在PPA条件下的食物摄入量（407克）比安慰剂条件下少26克（433克），但这种差异并不显著。然而，由于检验效能不足，无法接受零假设。PPA对摄入量的真实影响仍无定论。为了获得确定性结果，要么必须用这个剂量测试更多的受试者，要么通过改变剂量使效果更明显。
