Verleye M, Bernet F
Pharmacol Biochem Behav. 1987 Feb;26(2):421-4. doi: 10.1016/0091-3057(87)90140-7.
Intrahippocampal injections of adrenergic drugs, clonidine (an alpha 2-agonist), yohimbine (an alpha 2-antagonist), and salbutamol (a beta 2-agonist) were performed in the awake rat. The injection of a high dose of clonidine caused a depression in locomotion in the open-field. Yohimbine partially antagonized the clonidine-induced hypomotility. The intrahippocampal injection of salbutamol had no effect on ambulatory behavior of the rat. These results suggest that the role played by the anterodorsal hippocampus in modifying behavior in novel situations is dependent on the specific sub-population of adrenoceptors that is stimulated.
在清醒大鼠中进行海马内注射肾上腺素能药物，可乐定（一种α2激动剂）、育亨宾（一种α2拮抗剂）和沙丁胺醇（一种β2激动剂）。注射高剂量可乐定导致旷场实验中运动减少。育亨宾部分拮抗可乐定诱导的运动减少。海马内注射沙丁胺醇对大鼠的行走行为没有影响。这些结果表明，前背侧海马在新环境中调节行为所起的作用取决于所刺激的特定肾上腺素能受体亚群。
