Henke P G
Pharmacol Biochem Behav. 1987 Mar;26(3):561-3. doi: 10.1016/0091-3057(87)90166-3.
Intraperitoneal injections of chlordiazepoxide in rats attenuated the severity of stomach ulcers induced by a single restraint session. However, when the drug was withheld during the last session of a series of repeated restraint treatments, stomach erosions developed in the animals. Vehicle-controls, on the other hand, had adapted to the chronic stress, as indexed by a decline in gastric pathology. The results were discussed in reference to stress adaptation and drug withdrawal effects.
给大鼠腹腔注射氯氮卓可减轻单次束缚所致胃溃疡的严重程度。然而，在一系列重复束缚处理的最后一次处理期间停用该药时，动物出现了胃糜烂。另一方面，赋形剂对照组已适应慢性应激，这以胃部病理学变化的减轻为指标。结合应激适应和药物戒断效应讨论了研究结果。
