Voigt R, Eitz K, Bornschein M
Pharmazie. 1987 Jan;42(1):22-5.
Dissolution testing of hydrophobic powders with the flow-through method but without powder preparation doesn't guarantee accurate, reproducible and reasonable results in aqueous test media of high surface tension. Mixing drug powders with seasand or using fast desintegrating granules enables an exact determination and realistic valuation of the dissolution behaviour. Addition of surfactants generally accelerates the dissolution rate but problems as drug agglomeration and flotation remain.
采用流通法对疏水性粉末进行溶出度测试，但不进行粉末预处理，在高表面张力的水性测试介质中不能保证获得准确、可重现且合理的结果。将药物粉末与海沙混合或使用快速崩解颗粒能够准确测定并实际评估溶出行为。添加表面活性剂通常会加快溶出速率，但仍存在药物团聚和漂浮等问题。
