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T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis.

作者信息

Semic-Jusufagic Aida, Ogese Monday O, Edwards Christopher, Wilkinson Mark, Nissenbaum Claire, Lee Tim, Pirmohamed Munir, Naisbitt Dean J

机构信息

Paediatric Allergy, Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

出版信息

Pediatr Allergy Immunol. 2022 Jun;33(6):e13815. doi: 10.1111/pai.13815.

DOI:10.1111/pai.13815
PMID:35754124
Abstract
摘要

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T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis.囊性纤维化中T细胞介导的对鲁马卡托和依伐卡托的超敏反应。
Pediatr Allergy Immunol. 2022 Jun;33(6):e13815. doi: 10.1111/pai.13815.
2
Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial.在 F508del-CFTR 纯合子的 6-11 岁囊性纤维化患者中, lumacaftor 和 ivacaftor 的疗效和安全性:一项随机、安慰剂对照的 3 期临床试验。
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A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial.一种用于治疗携带 phe508del CFTR 突变的囊性纤维化患者的 CFTR 校正剂(芦卡帕替尼)和 CFTR 增强剂(依伐卡托):一项 2 期随机对照试验。
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Tezacaftor/ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events.特扎卡托/依伐卡托在因呼吸不良事件停止使用卢美卡托/依伐卡托的囊性纤维化患者中的应用。
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Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study.评估长期使用组合 Lumacaftor 和 Ivacaftor 疗法治疗囊性纤维化纯合子 F508del-CFTR 突变患者的安全性和疗效(PROGRESS):一项 3 期扩展研究。
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