Li G B, Wang Z J, Han J G
Department of General Surgery, Beijing Chaoyang Hosptial, Capital Medical University, Beijing 100020, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Jun 25;25(6):546-551. doi: 10.3760/cma.j.cn441530-20211111-00457.
Hereditary colorectal cancer accounts for approximately 5% of all colorectal cancer cases, mainly including familial adenomatous polyposis and Lynch syndrome. Total proctocolectomy plus ileal pouch-anal anastomosis and total colectomy plus ileorectal anastomosis are two major procedures for familial adenomatous polyposis, however, the exact impact of these two procedures on surgical efficacy, oncologic efficacy as well as functional results still remains uncertain. Segmental colectomy and total colectomy are two major procedures for Lynch syndrome, each of them both has advantages and disadvantages, and there still lacks a consensus about the optimal strategy because of the nature of retrospective study with a relatively insufficient evidence support. As a result, we would make a review about the current surgical treatment status and future perspectives of hereditary colorectal cancer.
遗传性结直肠癌约占所有结直肠癌病例的5%，主要包括家族性腺瘤性息肉病和林奇综合征。全直肠系膜切除术加回肠贮袋肛管吻合术和全结肠切除术加回肠直肠吻合术是家族性腺瘤性息肉病的两种主要手术方式，然而，这两种手术方式对手术疗效、肿瘤学疗效以及功能结果的确切影响仍不确定。节段性结肠切除术和全结肠切除术是林奇综合征的两种主要手术方式，它们各有优缺点，由于回顾性研究的性质且证据支持相对不足，对于最佳策略仍缺乏共识。因此，我们将对遗传性结直肠癌的当前外科治疗现状和未来前景进行综述。
