Department of Pulmonary, Critical care and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi.
Monaldi Arch Chest Dis. 2022 Jun 24;93(1). doi: 10.4081/monaldi.2022.2281.
The coronavirus disease 2019 (COVID-19) has affected different countries in a differential manner. The host susceptibility and host factors are important parameters for this variability. This study aimed to assess the effect of tuberculosis (TB) endemicity and Bacille Calmette-Guerin (BCG) coverage on COVID-19. Available data regarding TB incidence, BCG coverage (as per the World Health Organization), and COVID-19 incidence of 168 countries as of 19th September 2021was collected. Countries were divided into four cohorts based upon annual TB incidence and BCG coverage and COVID-19 incidence and case fatality rates were compared using the Kruskal-Wallis test. Countries with low TB incidence and low BCG coverage had the highest COVID-19 incidence per lac population. However, no significant difference was seen in COVID-19 cases fatality rate. Higher TB incidence and BCG coverage were associated with lesser incidence of COVID-19. This result paves the way for research into pathogenesis and host immune response in COVID-19.
2019 年冠状病毒病（COVID-19）以不同的方式影响了不同的国家。宿主易感性和宿主因素是这种变异性的重要参数。本研究旨在评估结核病（TB）流行程度和卡介苗（BCG）覆盖率对 COVID-19 的影响。截至 2021 年 9 月 19 日，收集了 168 个国家的结核病发病率、BCG 覆盖率（按世界卫生组织标准）和 COVID-19 发病率的数据。根据每年的结核病发病率和 BCG 覆盖率以及 COVID-19 的发病率和病死率，将这些国家分为四个队列，并使用 Kruskal-Wallis 检验进行比较。结核病发病率低且 BCG 覆盖率低的国家每 10 万人 COVID-19 发病率最高。然而，COVID-19 病死率没有显著差异。较高的结核病发病率和 BCG 覆盖率与 COVID-19 发病率较低相关。这一结果为 COVID-19 的发病机制和宿主免疫反应研究铺平了道路。
