Mishra Sarvesh Chandra, Gupta Aviral, Sharma Srishti, Gupta Archna
Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Int J Appl Basic Med Res. 2022 Apr-Jun;12(2):137-139. doi: 10.4103/ijabmr.ijabmr_620_21. Epub 2022 May 10.
Lane-Hamilton syndrome (LHS) is a rare syndromic association between idiopathic pulmonary hemosiderosis and celiac disease (CD). It is usually seen in children below 15 years of age. It can occasionally be seen in adults. We present the case of a 33-year-old female patient who presented with recurrent episodes of hemoptysis to the pulmonary outpatient department. She also gave a history of having frequent loose stools. She was admitted and investigated thoroughly and was found to be suffering from LHS which is a rare disease. High-resolution computed tomography (HRCT) of the chest and duodenal biopsy helped in concluding the diagnosis. She was started on gluten-free diet (GFD) and has responded well with no episodes of hemoptysis on 9-month follow-up and is in good general condition. This case highlights the importance of keeping a high index of suspicion of LHS in a young patient presenting with unexplained hemoptysis and diarrhea. In a known case of CD presenting with hemoptysis, a HRCT chest aids in the diagnosis of LHS. A GFD is the mainstay of long-term treatment, and adherence to this diet shows remarkable improvement in the symptoms of the patient and their overall general condition.
莱恩 - 汉密尔顿综合征(LHS)是特发性肺含铁血黄素沉着症与乳糜泻(CD)之间一种罕见的综合征关联。它通常见于15岁以下儿童,偶尔也可见于成人。我们报告一例33岁女性患者,她因反复咯血到肺科门诊就诊。她还诉说有频繁腹泻史。她入院后接受了全面检查,被发现患有LHS这种罕见疾病。胸部高分辨率计算机断层扫描(HRCT)和十二指肠活检有助于确诊。她开始接受无麸质饮食(GFD),在9个月的随访中反应良好,没有咯血发作,总体状况良好。该病例强调了对于出现不明原因咯血和腹泻的年轻患者,高度怀疑LHS的重要性。在已知患有CD且出现咯血的病例中,胸部HRCT有助于LHS的诊断。GFD是长期治疗的主要方法,坚持这种饮食可使患者症状及整体状况有显著改善。