Levin E D, Morgan M M, Galvez C, Ellison G D
Physiol Behav. 1987;39(4):441-4. doi: 10.1016/0031-9384(87)90370-2.
Female rats were used to examine the effects of chronic nicotine administration and withdrawal on food and water consumption and body weight. Rats with chronic nicotine pellet implants consumed significantly less food and water than controls for the first five days and then gradually returned to control levels of consumption. The lowest level of body weight was reached on day 9 after which there was a slow return to control weights by day 21. When the nicotine pellets were removed from the short-term exposure group on day 14, they showed significant hyperphagia and hyperdipsia and a very rapid weight gain for the next several days, which clearly outpaced the recovery of weight in the long-term nicotine exposure group. These results show that in female rats changes in weight during chronic nicotine administration and withdrawal are accompanied by changes in rates of consumption. In addition, nicotine withdrawal can cause hyperphagia and hyperdipsia even though levels of consumption had previously returned to control levels and even though the route of nicotine administration was not oral.
使用雌性大鼠来研究长期给予尼古丁及其戒断对食物和水消耗以及体重的影响。植入慢性尼古丁药丸的大鼠在前五天的食物和水消耗量明显低于对照组，然后逐渐恢复到对照水平。体重在第9天达到最低水平，之后到第21天缓慢恢复到对照体重。当在第14天将尼古丁药丸从短期暴露组取出时，它们在接下来的几天表现出明显的食欲亢进和饮水过多以及体重快速增加，这明显超过了长期尼古丁暴露组的体重恢复速度。这些结果表明，在雌性大鼠中，长期给予尼古丁及其戒断期间体重的变化伴随着消耗率的变化。此外，即使之前的消耗水平已恢复到对照水平，并且即使尼古丁的给药途径不是口服，尼古丁戒断也会导致食欲亢进和饮水过多。
