Li Xiao-Xiao, Wang Guan-Ru, Li Chao, He Na, Yao Peng, Cheng Yin-Chu, Wang Chu-Hui, Ge Qing-Gang, Yi Min, Wang Zong-Yu, Shi Lu-Wen, Zhao Rong-Sheng
Department of Pharmacy and Department of Intensive Care Unit, Peking University Third Hospital, Beijing, China.
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Front Med (Lausanne). 2022 Jun 9;9:829267. doi: 10.3389/fmed.2022.829267. eCollection 2022.
Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors and various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case of severe thrombocytopenia during intensive care unit (ICU) hospitalization that was likely to be associated with vancomycin. By revealing the process of identifying this case of DITP and reviewing relevant clinical studies, a risk alert of vancomycin-related severe hematotoxicity should be considered.
血小板减少症可导致危重症患者出现严重的发病率和死亡率。血小板减少症存在多种病因和相关机制，其中药物性血小板减少症（DITP）值得关注。在此，我们描述了1例在重症监护病房（ICU）住院期间发生的严重血小板减少症病例，该病例可能与万古霉素有关。通过揭示该DITP病例的识别过程并回顾相关临床研究，应考虑对万古霉素相关严重血液毒性发出风险警示。
