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血管肉瘤:一种与化学物质暴露相关的罕见恶性肿瘤。

Angiosarcoma: A Rare Malignancy Linked to Chemical Exposures.

作者信息

Tessema Sophia T, Mahgoub Abdullahi E, Nakhleh Rasha

机构信息

Neurology, Wayne State University, Detroit, USA.

Internal Medicine, Michigan State University / Hurley Medical Center, Flint, USA.

出版信息

Cureus. 2022 May 24;14(5):e25289. doi: 10.7759/cureus.25289. eCollection 2022 May.

Abstract

Angiosarcoma is an exceptionally rare malignancy that accounts for less than 1% of all sarcomas. This case describes a 90-year-old male veteran who presented with a hematoma from a traumatic head injury. This then progressed to an ulcerated bleeding lesion that measured 2.5 cm in diameter with pearly borders and granulation tissue. CT scan of the head and skin biopsy were consistent with the diagnosis of cutaneous angiosarcoma. The patient may have unique exposures from the military training site Camp Lejeune including tetrachloroethylene (PCE), trichloroethylene (TCE), trans-1,2-dichloroethylene, and vinyl chloride predisposing to angiosarcoma. The patient underwent palliative radiation without obvious complications. This case presents an opportunity for further evaluation and understanding of the effects of these exposures and the implications for the health of veterans and aging populations. Patient outcomes may be improved with earlier diagnosis and aggressive treatment.

摘要

血管肉瘤是一种极其罕见的恶性肿瘤,占所有肉瘤的比例不到1%。本病例描述了一名90岁的男性退伍军人,他因头部外伤出现血肿。随后发展为一个直径2.5厘米的溃疡出血性病变,边缘呈珍珠样,伴有肉芽组织。头部CT扫描和皮肤活检结果与皮肤血管肉瘤的诊断一致。该患者可能因曾在勒琼营军事训练基地接触过包括四氯乙烯(PCE)、三氯乙烯(TCE)、反式-1,2-二氯乙烯和氯乙烯等物质而易患血管肉瘤。患者接受了姑息性放疗,未出现明显并发症。本病例为进一步评估和了解这些暴露因素的影响以及对退伍军人和老年人群健康的影响提供了契机。早期诊断和积极治疗可能会改善患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f880/9224836/94cab04172e6/cureus-0014-00000025289-i01.jpg

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