Sacchetti Federico, Kilian Raphael, Muratori Francesco, Cherix Stephane, Foschi Lorenzo, Morganti Riccardo, Campanacci Domenico Andrea, Capanna Rodolfo
Department of Orthopaedic and Trauma Surgery, University of Pisa, Italy.
Department of Ophtalmology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Arch Bone Jt Surg. 2022 May;10(5):439-446. doi: 10.22038/ABJS.2021.58351.2889.
Megaprostheses are one of the preferred choices of reconstruction after tumor resection. Periprosthetic joint infections are one of the most serious complications of joint prostheses surgeries. In this study, our aim was to analyze the efficacy of silver-coated megaprostheses in reducing the risk of prosthesis-related infection.
One hundred forty-two patients who had undergone implantation of a mega-endoprosthesis for non-neoplastic or post-neoplastic conditions were included in this retrospective study. The end-point of the survival analysis was the prosthesis failure due to infection.
Thirty-eight patients had undergone implantation of a silver-coated megaprosthesis and 104 patients a megaprosthesis without silver coating. The survival analysis showed an overall infection-free survival rate of 82.3% at five years and 61.9% at 10 years. Silver-coated prostheses had an HR of 0.72 (95% CI: 0.26-2.05; ).
Implantation of a silver-coated mega-prosthesis in non-oncological patients did not significantly reduce the risk of prosthesis-related infection.
大假体是肿瘤切除术后重建的首选之一。假体周围关节感染是关节假体手术最严重的并发症之一。在本研究中，我们的目的是分析镀银大假体在降低假体相关感染风险方面的疗效。
本回顾性研究纳入了142例因非肿瘤性或肿瘤后情况接受大假体植入的患者。生存分析的终点是因感染导致的假体失败。
38例患者植入了镀银大假体，104例患者植入了无银涂层的大假体。生存分析显示，五年时总体无感染生存率为82.3%，十年时为61.9%。镀银假体的风险比为0.72（95%置信区间：0.26 - 2.05）。
在非肿瘤患者中植入镀银大假体并不能显著降低假体相关感染的风险。
