2-甲氧基-4-(((5-硝基吡啶-2-基)亚氨基)甲基)苯酚席夫碱配体及其铜(II)和锌(II)配合物：合成、表征及生物学研究
2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations.
作者信息
Deepika P, Vinusha H M, Begum Muneera, Ramu Ramith, Shirahatti Prithvi S, Nagendra Prasad M N
机构信息
Department of Chemistry, JSS Science and Technology University, Mysuru, Karnataka, 570 006, India.
PG Department of Chemistry, Sarada Vilas College, Mysuru, 570004, India.
出版信息
Heliyon. 2022 Jun 6;8(6):e09648. doi: 10.1016/j.heliyon.2022.e09648. eCollection 2022 Jun.
In this current work we have prepared a Schiff base ligand, () derived from 5- nitropyridine-2-amine with 4-hydroxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, H-NMR, C-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of assays viz., DPPH, ABTS and Superoxide where BHA was used as a positive controller. -glucosidase inhibitory activities showed that complexes had considerable inhibitory potential when compared to the ligand.
在当前这项工作中，我们制备了一种席夫碱配体，（）它由5-硝基吡啶-2-胺与4-羟基-3-甲氧基苯甲醛反应得到，以及其与铜（II）和锌（II）以2:1化学计量比（2HL:M）形成的配合物。通过质谱（MS）、傅里叶变换红外光谱（FT-IR）、紫外可见光谱（UV-Visible）、氢核磁共振光谱（H-NMR）、碳核磁共振光谱（C-NMR）和热重分析方法对配体和金属配合物的形成进行了评估。通过一系列测定，即二苯基苦味酰基自由基（DPPH）、2,2'-联氮-双-3-乙基苯并噻唑啉-6-磺酸（ABTS）和超氧阴离子测定，评估了化合物的自由基清除活性，其中丁基羟基茴香醚（BHA）用作阳性对照。α-葡萄糖苷酶抑制活性表明，与配体相比，配合物具有相当大的抑制潜力。
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