Nguyen Martin V, Loof Lydia, Falchook Gerald S
Sarah Cannon Research Institute at HealthONE, Denver, CO, USA.
J Immunother Precis Oncol. 2020 Feb 5;3(1):16-22. doi: 10.4103/JIPO.JIPO_2_20. eCollection 2020 Feb.
The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers.
溴结构域和额外末端（BET）结构域蛋白家族参与遗传信息的转录过程。BET蛋白家族包括BRD2、BRD3、BRD4和睾丸特异性溴结构域蛋白。BET蛋白改变与一些实体肿瘤癌症相关，包括睾丸中线癌中的核蛋白。BET蛋白在致癌作用和细胞周期调控中发挥作用。多种BET抑制剂已进入临床试验。本综述讨论了BET抑制剂在实体肿瘤癌症临床试验中的结果。
