Lavecchia Angelo Michele, Buttò Sara, Xinaris Christodoulos
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
MethodsX. 2022 Jun 9;9:101753. doi: 10.1016/j.mex.2022.101753. eCollection 2022.
Insufficient production of erythropoietin (EPO) leads to anaemia. Developing methods for the generation and transplantation of EPO-producing cells would allow scientists to design personalised therapeutic solutions. Here we present a simple and highly reproducible protocol for the generation of neural crest cells (NCCs) that can produce and secrete erythropoiesis-competent EPO in response to hypoxia.
促红细胞生成素（EPO）分泌不足会导致贫血。开发生成和移植产生EPO细胞的方法，将使科学家能够设计个性化的治疗方案。在此，我们展示了一种简单且高度可重复的方案，用于生成神经嵴细胞（NCCs），这些细胞能够在缺氧时产生并分泌具有促红细胞生成能力的EPO。
