血清白细胞介素-6、NF-B 加 MCP-1 测定对糖尿病肾病患者的预后价值。

Prognostic Value of Serum Interleukin-6, NF-B plus MCP-1 Assay in Patients with Diabetic Nephropathy.

机构信息

The Clinical Laboratory of Lianyungang Oriental Hospital, The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, Lianyungang, China.

The Department of Pharmacy of Lianyungang Oriental Hospital, The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, China.

出版信息

Dis Markers. 2022 Jun 17;2022:4428484. doi: 10.1155/2022/4428484. eCollection 2022.

DOI:10.1155/2022/4428484

PMID:35756496

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9232375/

Abstract

OBJECTIVE

To assess the prognostic value of serum interleukin-6 (IL-6), nuclear factor-B (NF-B), and monocyte chemoattractant protein 1(MCP-1) assay in patients with diabetic nephropathy.

METHODS

From May 2019 to March 2020, 104 patients with diabetic nephropathy treated in our institution assessed for eligibility were recruited and assigned at a ratio of 1 : 1 to either the observation group ([urinary albumin excretion rate (UAER)] of 30 mg-300 mg/24 h) or the research group ([UAER] >300 mg/24 h). IL-6, MCP-1, renal function indices, and NF-B levels were determined, and their correlation with DN was analyzed. Logistic regression was used to analyze the influencing factors of end-stage renal disease in patients with diabetic nephropathy. The receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) was calculated to analyze the predictive value of combined detection of IL-6, MCP-1, and NF-B in the prognosis of patients with diabetic nephropathy.

RESULTS

The eligible patients with UAER of 30 mg-300 mg/24 h were associated with significantly higher levels of IL-6, MCP-1, NF-B, blood urea nitrogen (BUN), and serum creatinine (Scr) versus those with UAER >300 mg/24 h ( < 0.05). During the follow-up, a total of 38 patients progressed to end-stage renal diseases. Eligible patients with end-stage renal diseases showed significantly higher serum IL-6, MCP-1, and NF-B levels versus those without end-stage renal diseases ( < 0.05). Serum IL-6, MCP-1, and NF-B are independent risk factors for the occurrence of end-stage renal disease in patients with diabetic nephropathy. The AUCs of IL-6, MCP-1, and NF-B for predicting the prognosis of patients with diabetic nephropathy were 0.562, 0.634, and 0.647, respectively, and the AUC of the three combined detection for predicting the prognosis of patients with diabetic nephropathy was 0.889.

CONCLUSION

Serum IL-6, NF-B, and MCP-1 levels are closely related to renal injury and poor prognosis in patients with diabetic nephropathy, and the combined assay is valuable for assessing patients' condition and prognosis.

摘要

目的

评估血清白细胞介素 6（IL-6）、核因子-B（NF-B）和单核细胞趋化蛋白 1（MCP-1）检测在糖尿病肾病患者中的预后价值。

方法

2019 年 5 月至 2020 年 3 月，我院收治的 104 例糖尿病肾病患者符合入选标准，并按照 1:1 的比例分为观察组（尿白蛋白排泄率（UAER）为 30~300mg/24h）和研究组（UAER＞300mg/24h）。检测 IL-6、MCP-1、肾功能指标和 NF-B 水平，并分析其与 DN 的相关性。采用 logistic 回归分析糖尿病肾病患者终末期肾病的影响因素。绘制受试者工作特征（ROC）曲线，计算曲线下面积（AUC），分析 IL-6、MCP-1 和 NF-B 联合检测对糖尿病肾病患者预后的预测价值。

结果

UAER 为 30~300mg/24h 的合格患者的 IL-6、MCP-1、NF-B、血尿素氮（BUN）和血清肌酐（Scr）水平明显高于 UAER＞300mg/24h 的患者（<0.05）。随访期间，共有 38 例患者进展为终末期肾病。终末期肾病合格患者的血清 IL-6、MCP-1 和 NF-B 水平明显高于无终末期肾病的患者（<0.05）。血清 IL-6、MCP-1 和 NF-B 是糖尿病肾病患者发生终末期肾病的独立危险因素。IL-6、MCP-1 和 NF-B 预测糖尿病肾病患者预后的 AUC 分别为 0.562、0.634 和 0.647，三种联合检测预测糖尿病肾病患者预后的 AUC 为 0.889。