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三瓣膜手术中使用生物胶引发的脑栓塞性阵雨。

Cerebral embolic shower secondary to BioGlue use in triple valve surgery.

作者信息

Rajan Venkatesa Kumar Anakaputhur, Kasturi Srikanth, Soundararajan Niranjan, Sinha Priyankar

机构信息

Department of Cardiothoracic Surgery, Narayana Institute of Cardiac Sciences, 258/A, Hosur Road, Bommasandra Industrial Area, Anekal Taluk, Bengaluru, Karnataka 560099 India.

出版信息

Indian J Thorac Cardiovasc Surg. 2022 Jul;38(4):426-429. doi: 10.1007/s12055-022-01344-z. Epub 2022 Mar 30.

DOI:10.1007/s12055-022-01344-z
PMID:35756566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9218018/
Abstract

Hemostasis is a crucial step in cardiac surgery which determines postoperative outcomes. Tissue sealants and glues are necessary to achieve hemostasis in situations where conventional methods are unsuccessful. BioGlue, a commonly used topical hemostatic agent, has been reported to cause systemic embolic complications. We report a case of cerebral embolic shower following the use of BioGlue for posterior aortic suture line bleeding in a 49-year-old lady who underwent triple valve surgery. This report brings to light a rare but devastating complication of BioGlue usage in the present era of complex aortic surgeries. We also postulate a mechanism for BioGlue embolization.

摘要

止血是心脏手术中的关键步骤,它决定了术后的结果。在传统方法无法成功止血的情况下,组织密封剂和胶水对于实现止血是必要的。生物胶是一种常用的局部止血剂,据报道会引起全身性栓塞并发症。我们报告了一例在一名接受三瓣膜手术的49岁女性中,使用生物胶治疗主动脉后缝合线出血后发生脑栓塞性阵雨的病例。本报告揭示了在当今复杂主动脉手术时代使用生物胶罕见但具有毁灭性的并发症。我们还推测了生物胶栓塞的机制。

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1
Cerebral embolic shower secondary to BioGlue use in triple valve surgery.三瓣膜手术中使用生物胶引发的脑栓塞性阵雨。
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本文引用的文献

1
BioGlue coronary embolism during open heart surgery.心脏直视手术期间的生物胶冠状动脉栓塞。
J Cardiol Cases. 2014 Jun 25;10(2):78-80. doi: 10.1016/j.jccase.2014.05.007. eCollection 2014 Aug.
2
Changes over Time in Intracranial Air in Patients with Cerebral Air Embolism: Radiological Study in Two Cases.脑空气栓塞患者颅内气体随时间的变化:两例病例的放射学研究
Case Rep Neurol Med. 2015;2015:491017. doi: 10.1155/2015/491017. Epub 2015 Nov 12.
3
Pulmonary embolism due to biological glue after repair of type A aortic dissection.A型主动脉夹层修复术后生物胶所致肺栓塞
Interact Cardiovasc Thorac Surg. 2011 Apr;12(4):650-1. doi: 10.1510/icvts.2010.261933. Epub 2011 Jan 27.
4
A review of topical hemostatic agents for use in cardiac surgery.心脏手术中局部止血剂的综述。
Ann Thorac Surg. 2009 Oct;88(4):1377-83. doi: 10.1016/j.athoracsur.2009.02.092.
5
The threat of adhesive embolization: BioGlue leaks through needle holes in aortic tissue and prosthetic grafts.粘连栓塞的风险:生物胶会通过主动脉组织和人工血管的针孔渗漏。
Ann Thorac Surg. 2005 Jul;80(1):106-10; discussion 110-1. doi: 10.1016/j.athoracsur.2005.02.004.
6
BioGlue: albumin/glutaraldehyde sealant in cardiac surgery.生物胶:心脏手术中使用的白蛋白/戊二醛密封剂。
J Card Surg. 2003 Nov-Dec;18(6):500-3. doi: 10.1046/j.0886-0440.2003.00304.x.
7
Prospective randomized study of a protein-based tissue adhesive used as a hemostatic and structural adjunct in cardiac and vascular anastomotic repair procedures.一项关于在心脏和血管吻合修复手术中用作止血和结构辅助剂的蛋白质基组织粘合剂的前瞻性随机研究。
J Am Coll Surg. 2003 Aug;197(2):243-52; discussion 252-3. doi: 10.1016/S1072-7515(03)00376-4.
8
Embolization of biologic glue during repair of aortic dissection.主动脉夹层修复术中生物胶的栓塞
Ann Thorac Surg. 1995 Oct;60(4):1118-20. doi: 10.1016/0003-4975(95)97585-b.