Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications.

The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase () 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to wild-type (-wt) counterparts. Moreover, the -wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (amp) and mutation of the promoter of telomerase reverse transcriptase (). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG.