Lumb Bridget M, Donaldson Lucy F
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, United Kingdom.
Front Pain Res (Lausanne). 2022 Jun 9;3:910471. doi: 10.3389/fpain.2022.910471. eCollection 2022.
Descending pain modulatory systems (DPMS) that originate within the brain and act to modulate spinal nociceptive transmission are a major determinant of the acute and chronic pain experience. Investigations of these systems in basic scientific research is critical to the development of therapeutic strategies for the relief of pain. Despite our best efforts, something is lost in translation. This article will explore whether this is due in part to a primary focus on sensory modality leading to a failure to differentiate between descending control of A- vs. C-fiber mediated spinal nociception.
起源于大脑并作用于调节脊髓伤害性感受传递的下行性疼痛调制系统（DPMS）是急性和慢性疼痛体验的主要决定因素。在基础科学研究中对这些系统进行调查对于开发缓解疼痛的治疗策略至关重要。尽管我们已尽最大努力，但在翻译过程中仍有所遗漏。本文将探讨这是否部分归因于主要关注感觉模态，导致未能区分A纤维与C纤维介导的脊髓伤害性感受的下行控制。
