当速度的差异下行控制起作用时：A 类与 C 类纤维诱发的脊髓伤害性感受的下行调制
When Differential Descending Control of Speed Matters: Descending Modulation of A- versus C-Fiber Evoked Spinal Nociception.
作者信息
Lumb Bridget M, Donaldson Lucy F
机构信息
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, United Kingdom.
出版信息
Front Pain Res (Lausanne). 2022 Jun 9;3:910471. doi: 10.3389/fpain.2022.910471. eCollection 2022.
Abstract
Descending pain modulatory systems (DPMS) that originate within the brain and act to modulate spinal nociceptive transmission are a major determinant of the acute and chronic pain experience. Investigations of these systems in basic scientific research is critical to the development of therapeutic strategies for the relief of pain. Despite our best efforts, something is lost in translation. This article will explore whether this is due in part to a primary focus on sensory modality leading to a failure to differentiate between descending control of A- vs. C-fiber mediated spinal nociception.
摘要
起源于大脑并作用于调节脊髓伤害性感受传递的下行性疼痛调制系统（DPMS）是急性和慢性疼痛体验的主要决定因素。在基础科学研究中对这些系统进行调查对于开发缓解疼痛的治疗策略至关重要。尽管我们已尽最大努力，但在翻译过程中仍有所遗漏。本文将探讨这是否部分归因于主要关注感觉模态，导致未能区分A纤维与C纤维介导的脊髓伤害性感受的下行控制。
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本文引用的文献
1
An ultrafast system for signaling mechanical pain in human skin.一种用于探测人类皮肤机械性疼痛的超快系统。
Sci Adv. 2019 Jul 3;5(7):eaaw1297. doi: 10.1126/sciadv.aaw1297. eCollection 2019 Jul.
2
Phenotype and Function of Somatic Primary Afferent Nociceptive Neurones with C-, Aδ- or Aα/β-Fibres.具有C纤维、Aδ纤维或Aα/β纤维的躯体初级传入伤害性神经元的表型与功能
Exp Physiol. 2002 Mar;87(2):239-244. doi: 10.1113/eph8702350.
3
Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity.导水管周围灰质EP3受体促进关节炎继发性超敏反应中的脊髓伤害感受。
J Neurosci. 2016 Aug 31;36(35):9026-40. doi: 10.1523/JNEUROSCI.4393-15.2016.
4
Differential contributions of A- and C-nociceptors to primary and secondary inflammatory hypersensitivity in the rat.A类和C类伤害感受器对大鼠原发性和继发性炎症性超敏反应的不同作用。
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