Deuter Christian Eric, Smit Janna, Kaczmarczyk Michael, Wingenfeld Katja, Otte Christian, Kuehl Linn Kristina
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Compr Psychoneuroendocrinol. 2021 Aug 1;8:100077. doi: 10.1016/j.cpnec.2021.100077. eCollection 2021 Nov.
Adverse childhood experiences (ACE) are a major risk factor for major depressive disorder (MDD) in later life. Both conditions are characterized by dysregulations in the noradrenergic system related which again could represent a mediating mechanism for deficits in affective processing and behavioral functioning. In this double-blind, placebo-controlled study we tested the hypothesis that ACE and MDD are characterized by aberrant approach-avoidance (AA) tendencies and that these are mitigated after noradrenergic stimulation with yohimbine. In a mixed-measures, fully crossed design, participants (N = 131, 73 women) with/without MDD and with/without ACE received a single-dose of yohimbine or placebo on different days, followed by an AA task. We found modulation of AA tendencies by the emotional valence of target images, yet there were no effects of group or treatment. From these results, we conclude that AA tendencies are not critically affected by MDD or ACE and that the noradrenergic system is not substantially involved in this behavior.
童年不良经历（ACE）是日后患重度抑郁症（MDD）的主要风险因素。这两种情况都表现为去甲肾上腺素能系统失调，而这又可能是情感加工和行为功能缺陷的一种中介机制。在这项双盲、安慰剂对照研究中，我们检验了以下假设：ACE和MDD的特征是异常的趋近-回避（AA）倾向，并且在用育亨宾进行去甲肾上腺素能刺激后这些倾向会得到缓解。在一个混合测量、完全交叉设计中，有/无MDD以及有/无ACE的参与者（N = 131，73名女性）在不同日期接受单剂量的育亨宾或安慰剂，然后进行AA任务。我们发现目标图像的情感效价对AA倾向有调节作用，但没有发现组间或治疗的效应。从这些结果来看，我们得出结论：AA倾向不受MDD或ACE的严重影响，并且去甲肾上腺素能系统在这种行为中没有实质性参与。
