School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, United Kingdom.
Laboratory on Thymus Research, Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
Front Immunol. 2022 Jun 10;13:874064. doi: 10.3389/fimmu.2022.874064. eCollection 2022.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition.
PROSPERO, identifier CRD42022306558.
自闭症谱系障碍 (ASD) 是一种异质性神经发育障碍，其特征为刻板行为、特定兴趣和沟通技能受损。高水平的促炎细胞因子，如白细胞介素-17A (IL-17A 或 IL-17)，被认为是导致这种结果的免疫改变的一部分。在这种情况下，啮齿动物模型有助于阐明 T 细胞激活和 IL-17 分泌在 ASD 发病机制中的作用。关于临床前发现，现有数据在后代中存在矛盾，但在孕鼠中则没有，这表明 IL-17 是一些 ASD 模型中改变行为的主要驱动因素之一，而在其他模型中则没有描述 IL-17 水平的改变。为了弥补这一文献空白，对 ASD 啮齿动物模型中改变的 IL-17 水平进行了系统评价。总共纳入了 28 项探讨 IL-17 水平的研究，观察到这种细胞因子在不同的 ASD 模型中通常增加。本综述中汇编的数据可以帮助选择动物模型来研究细胞因子在 ASD 发展中的作用，以寻求与该疾病患者中观察到的免疫改变的平行关系。
PROSPERO，标识符 CRD42022306558。
