Corsello Andrea
Recenti Prog Med. 2022 Jun;113(6):7e-10e. doi: 10.1701/3827.38157.
Resistance to thyroid hormone (RTH) is a genetic syndrome defined by an impaired sensitivity to thyroid hormones. It is characterized by discrepancies between the blood levels of thyroid hormones (FT3, FT4) and TSH, and by the coexistence of hypothyroidism and hyperthyroidism symptoms. Here we describe the case of a patient affected with thyroid cancer and RTH in whom it was difficult to obtain a good control of TSH after total thyroidectomy despite high doses of thyroxine replacement therapy. This represents a unique model to improve the understanding of the alterations in the feedback mechanism in patients with RTH and to optimize the replacement therapy in patients with concomitant thyroid cancer who need adequate TSH control.
甲状腺激素抵抗（RTH）是一种遗传性综合征，其定义为对甲状腺激素的敏感性受损。它的特征是甲状腺激素（FT3、FT4）的血液水平与促甲状腺激素（TSH）之间存在差异，以及甲状腺功能减退和甲状腺功能亢进症状并存。在此，我们描述了一例患有甲状腺癌和RTH的患者，尽管进行了高剂量的甲状腺素替代治疗，但在全甲状腺切除术后仍难以实现对TSH的良好控制。这代表了一个独特的模型，有助于提高对RTH患者反馈机制改变的理解，并优化对需要充分控制TSH的合并甲状腺癌患者的替代治疗。
