Division of Gastroenterology, Wuhan No. 1 Hospital, 215 Zhongshan Road, Wuhan, China.
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, China.
Medicine (Baltimore). 2022 Jun 24;101(25):e29211. doi: 10.1097/MD.0000000000029211.
The possible association between shift work with irritable bowel syndrome (IBS) and functional dyspepsia (FD) remains controversial. The purpose of the study is to conduct a meta-analysis to explore the potential association between shift work with IBS/FD.
We searched relevant observational studies on Medline (PubMed) and Embase until June 30, 2021. Two different investigators extracted data and assessed the quality of each study independently. The meta-analysis was used to evaluate the pooled odds risk (OR) between shift work and IBS/FD.
Eight studies were included ultimately. Shift workers were more likely to suffer from IBS. The OR of shift work was 1.81 (95% confidence interval 1.42; 2.32) with low heterogeneity (P < .05, I2 = 0%) for IBS. However, no evidence of the association was observed between shift work and the risk of FD. The OR of shift work was 0.87 (95% confidence interval 0.62; 1.23) (P > .05) for FD.
There was a positive association between shift work and IBS. The prevalence of IBS was 81% higher among shift workers than among non-shift workers. Shift work was probably a risk factor for IBS. The low heterogeneity supports the reliability of the results. However, there was no significant association between shift work and FD. The strength of the evidence was limited and further prospective cohort studies were needed.
轮班工作与肠易激综合征（IBS）和功能性消化不良（FD）之间的可能关联仍存在争议。本研究的目的是进行荟萃分析，以探讨轮班工作与 IBS/FD 之间的潜在关联。
我们在 Medline（PubMed）和 Embase 上搜索了截至 2021 年 6 月 30 日的相关观察性研究。两名不同的调查员独立提取数据并评估每项研究的质量。使用荟萃分析评估轮班工作与 IBS/FD 之间的汇总优势比（OR）。
最终纳入了 8 项研究。轮班工作者更有可能患 IBS。轮班工作的 OR 为 1.81（95%置信区间 1.42；2.32），异质性低（P<0.05，I2=0%），表明 IBS 存在关联。然而，轮班工作与 FD 风险之间没有观察到关联。轮班工作的 OR 为 0.87（95%置信区间 0.62；1.23）（P>.05），表明 FD 不存在关联。
轮班工作与 IBS 之间存在正相关。轮班工作者的 IBS 患病率比非轮班工作者高 81%。轮班工作可能是 IBS 的一个危险因素。低异质性支持结果的可靠性。然而，轮班工作与 FD 之间没有显著关联。证据的强度有限，需要进一步进行前瞻性队列研究。
