Department of Nuclear Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Department of Nuclear Medicine, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Medicine (Baltimore). 2022 Jun 24;101(25):e29515. doi: 10.1097/MD.0000000000029515.
Technetium-99m methyl diphosphonate bone scintigraphy is relatively easily accessible for detecting bone metastases in prostate cancer patients. However, it is subjective and can be challenging to compare images taken at different time points. The bone scan index (BSI) is a more objective evaluation and allows for better comparison of images. Its correlation with other biomarkers of prostate cancer metastases such as prostate specific antigen (PSA) and alkaline phosphatase (ALP) is not clearly understood. This study thus aimed to compare the BSI correlation to PSA against that of BSI to ALP levels in patients with a Gleason score ≥7.A retrospective analysis of the medical records of 50 prostate cancer patients with a Gleason score of ≥7 referred for a bone scan between January 1, 2015 and December 31, 2018 was undertaken. Bone scans were interpreted visually, and using a semi-automated computer programme to quantify the BSI and its relation to PSA and ALP measurements.For the metastasis positive measurements, there was a statistically significant moderate positive overall linear correlation between BSI and PSA. For ALP and BSI, there were 2 segmented strong positive linear relationships between them. The first segment consisted of ALP < 375 IU/L and BSI >10%, where ALP and BSI were strongly and positively correlated. The other segment tended to have generally low BSI measurements (<10%) and also had a strong and positive correlation.The BSI was found to be better linearly correlated with ALP than PSA.
锝 99m 亚甲基二膦酸盐骨闪烁扫描术在检测前列腺癌患者的骨转移方面相对容易。然而，它具有主观性，并且在比较不同时间点拍摄的图像时可能具有挑战性。骨扫描指数（BSI）是一种更客观的评估方法，可更好地比较图像。它与前列腺特异性抗原（PSA）和碱性磷酸酶（ALP）等其他前列腺癌转移的生物标志物的相关性尚不清楚。因此，本研究旨在比较 BSI 与 PSA 的相关性与 BSI 与 ALP 水平在 Gleason 评分≥7 的患者中的相关性。
回顾性分析了 2015 年 1 月 1 日至 2018 年 12 月 31 日期间因骨扫描而转诊的 50 名 Gleason 评分≥7 的前列腺癌患者的病历。对骨扫描进行了视觉解释，并使用半自动计算机程序来定量 BSI 及其与 PSA 和 ALP 测量值的关系。
对于阳性转移测量值，BSI 与 PSA 之间存在统计学上显著的中度正线性相关。对于 ALP 和 BSI，它们之间存在 2 个分段的强正线性关系。第一个部分包括 ALP <375 IU/L 和 BSI >10%，其中 ALP 和 BSI 呈强正相关。另一个部分倾向于具有一般较低的 BSI 测量值（<10%），并且也具有强正相关。
BSI 与 ALP 的线性相关性优于 PSA。
