AL-NU'MAN TEACHING HOSPITAL, BAGHDAD, IRAQ.
AL- NAHRAIN UNIVERSITY, BAGHDAD, IRAQ.
Wiad Lek. 2022;75(5 pt 2):1268-1273. doi: 10.36740/WLek202205207.
The aim: A prospective randomized comparative study was conducted to investigate the effect of dual trigger, using gonadotropin releasing hormone agonist with human chorionic gonadotropin (hCG) versus hCG alone, for ovulation trigger in controlled ovarian stimulation intrauterine insemination (IUI) cycle on pregnancy outcome.
Materials and methods: Ninety women were randomly allocated into equal groups to trigger ovulation for IUI cycle using either method; IUI was performed following 36-42 hours post triggering. Luteinizing hormone (LH) and progesterone levels were measured at insemination day.
Results: The baseline of demographic and clinical characteristics of both groups was similar. Progesterone level was higher in dual trigger group than in hCG alone group (1.61 versus 0.71 ng/mL, P≤0.0001); while LH level was lower in dual trigger group (19.35 versus 24.51 IU/L, P≤0.014). Furthermore, LH level at the day of IUI was higher in pregnant women than in non-pregnant (27.9 versus 20 IU/L, P≤0.007).
Conclusions: Pregnancy rate was equivalent in both groups. More intensive investigation is required to study the efficacy of the dual trigger in IUI cycle.
前瞻性随机对照研究旨在探讨在控制性卵巢刺激宫内授精（IUI）周期中使用促性腺激素释放激素激动剂联合人绒毛膜促性腺激素（hCG）与单独使用 hCG 触发排卵对妊娠结局的影响。
90 名女性被随机分配到两组，分别采用两种方法触发排卵用于 IUI 周期；触发后 36-42 小时进行 IUI。在授精日测量黄体生成素（LH）和孕酮水平。
两组的人口统计学和临床特征基线相似。双重触发组的孕酮水平高于单独使用 hCG 组（1.61 对 0.71ng/mL，P≤0.0001）；而双重触发组的 LH 水平较低（19.35 对 24.51IU/L，P≤0.014）。此外，妊娠组的 IUI 日 LH 水平高于非妊娠组（27.9 对 20IU/L，P≤0.007）。
两组的妊娠率相当。需要更深入的研究来探讨双重触发在 IUI 周期中的疗效。
