美托咪定-氯胺酮-丁丙诺啡麻醉地下孤鼠沙鼠（）和海角鼠（）。

MEDETOMIDINE-KETAMINE-BUPRENORPHINE ANESTHESIA OF THE SOLITARY SUBTERRANEAN CAPE DUNE MOLE-RAT () AND THE CAPE MOLE-RAT ().

机构信息

Werribee Open Range Zoo, Veterinary Hospital, Zoos Victoria, Victoria, 3029, Australia,

Department of Zoology & Entomology, University of Pretoria, Hatfield, Pretoria, 0002, South Africa.

出版信息

J Zoo Wildl Med. 2022 Jun;53(2):357-362. doi: 10.1638/2019-0164.

DOI:10.1638/2019-0164

PMID:35758577

Abstract

A prospective, descriptive study was conducted to evaluate the safety and efficacy of a field-ready anesthetic drug combination of medetomidine-ketamine-buprenorphine for data logger implantation surgery or recheck in free-ranging Cape dune (: = 41) and Cape (: = 37) mole-rats. All anesthesia data were reported as mean (±standard deviation). Medetomidine-ketamine-buprenorphine doses were 0.1 (±0.03), 10.6 (±2.8), and 0.06 (±0.03) mg/kg, respectively, for Cape dune mole-rats; and 0.2 (±0.03), 19.4 (±4.0), and 0.14 (±0.03) mg/kg, respectively, for Cape mole-rats. Induction was calm and took 2.00 (range: 1.00-6.00) min for the Cape dune and 1.75 (range 1.25 to 8.16) min for Cape mole-rats. A surgical plane of anesthesia was achieved in most Cape dune mole-rats (92%) and Cape mole-rats (90%). The remainder required supplementation with a single intramuscular injection of ketamine (3-9 mg/kg) during surgery. Heart and respiratory rates were 149 (±37) beats and 24 (±8) breaths per minute, respectively, for Cape dune mole-rats and 179 (±40) beats and 25 (±10) and breaths per minute, respectively for Cape mole-rats. Surgical time for mole-rats ranged from 25 to 38 min. Recovery was calm and took 8.50 (range: 2.00-19.00) min for Cape dune mole-rats and 9.75 (range: 2.00-34.00) min for Cape mole-rats to recover. For recovery, atipamezole was administered intramuscularly at 0.5 (±0.15) mg/kg for Cape dune mole-rats and 1 (±0.15) mg/kg for Cape mole-rats. All mole-rats were returned to their original burrows within 48 h of recovery. The medetomidine-ketamine-buprenorphine combination induced a predictable, safe anesthesia in Cape dune and Cape mole-rats suitable for short intraabdominal surgery. This combination is suited to in situ studies where the use of a formal surgery or laboratory is not feasible.

摘要

一项前瞻性描述性研究评估了一种现成的麻醉药物组合（美托咪定-氯胺酮-丁丙诺啡）在自由放养的开普沙丘（n = 41）和开普海角（n = 37）鼹鼠中用于数据记录器植入手术或复查的安全性和有效性。所有麻醉数据均以平均值（±标准差）报告。美托咪定-氯胺酮-丁丙诺啡的剂量分别为 Cape dune 鼹鼠 0.1（±0.03）mg/kg、10.6（±2.8）mg/kg 和 0.06（±0.03）mg/kg；Cape mole-rats 为 0.2（±0.03）mg/kg、19.4（±4.0）mg/kg 和 0.14（±0.03）mg/kg。诱导过程平静，开普沙丘鼹鼠的诱导时间为 2.00 分钟（范围：1.00-6.00 分钟），开普海角鼹鼠的诱导时间为 1.75 分钟（范围 1.25 至 8.16 分钟）。大多数 Cape dune 鼹鼠（92%）和 Cape mole-rats（90%）达到了手术麻醉平面。其余的需要在手术期间单次肌肉注射氯胺酮（3-9 mg/kg）进行补充。Cape dune 鼹鼠的心率和呼吸频率分别为 149（±37）次/分钟和 24（±8）次/分钟，Cape mole-rats 的心率和呼吸频率分别为 179（±40）次/分钟和 25（±10）次/分钟。鼹鼠的手术时间为 25-38 分钟。恢复过程平静，开普沙丘鼹鼠的恢复时间为 8.50 分钟（范围：2.00-19.00 分钟），开普海角鼹鼠的恢复时间为 9.75 分钟（范围：2.00-34.00 分钟）。恢复时，肌肉注射 0.5（±0.15）mg/kg 阿替美唑用于 Cape dune 鼹鼠，1（±0.15）mg/kg 阿替美唑用于 Cape mole-rats。所有鼹鼠在恢复后 48 小时内都被送回原来的洞穴。美托咪定-氯胺酮-丁丙诺啡组合诱导出一种可预测的、安全的 Cape dune 和 Cape mole-rats 麻醉效果，适用于短时间的腹腔内手术。这种组合适用于原位研究，在原位研究中，使用正式手术或实验室是不可行的。