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2
Successful treatment of paraneoplastic longitudinally extensive transverse myelitis (LETM): A 16-month clinical-spinal MRI follow-up.成功治疗副肿瘤性长节段横贯性脊髓炎(LETM):16 个月的临床-脊髓 MRI 随访。
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3
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Modifications of longitudinally extensive transverse myelitis and brainstem lesions in the course of neuromyelitis optica (NMO): a population-based, descriptive study.视神经脊髓炎(NMO)病程中长节段横贯性脊髓炎和脑干病变的改变:一项基于人群的描述性研究。
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Longitudinally extensive transverse myelitis immune-mediated in aquaporin-4 antibody negative patients: Disease heterogeneity.水通道蛋白4抗体阴性患者中免疫介导的纵向广泛横贯性脊髓炎:疾病异质性
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[Longitudinally Extensive Transverse Myelitis Caused by Granulomatous Primary Central Nervous System Vasculitis with Characteristic Brain Magnetic Resonance Image: A Case Report].[肉芽肿性原发性中枢神经系统血管炎伴特征性脑磁共振成像导致的纵向广泛横贯性脊髓炎:一例报告]
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Intravascular lymphoma presenting as a longitudinally-extensive myelitis: diagnostic challenges and etiologic clues.血管内淋巴瘤表现为长节段性脊髓炎:诊断挑战和病因线索。
J Neurol Sci. 2011 Apr 15;303(1-2):146-9. doi: 10.1016/j.jns.2010.12.016. Epub 2011 Jan 17.
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Differentiating neuromyelitis optica from other causes of longitudinally extensive transverse myelitis on spinal magnetic resonance imaging.在脊髓磁共振成像上鉴别视神经脊髓炎与其他导致长节段横贯性脊髓炎的病因。
Mult Scler. 2016 Mar;22(3):302-11. doi: 10.1177/1352458515591069. Epub 2015 Jul 24.

本文引用的文献

1
Neuroinflammation preceding primary central nervous system lymphoma (PCNSL) - Case reports and literature review.神经炎症先于原发性中枢神经系统淋巴瘤(PCNSL)-病例报告和文献复习。
J Clin Neurosci. 2021 Jul;89:381-388. doi: 10.1016/j.jocn.2021.05.038. Epub 2021 Jun 1.
2
Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.更新后的副肿瘤性神经系统综合征诊断标准。
Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4). doi: 10.1212/NXI.0000000000001014. Print 2021 Jul.
3
Inflammatory Demyelinating Lesions: True Sentinel Lesion or Immune-Mediated Response to Lymphoma?炎性脱髓鞘病变:真正的首发病变还是淋巴瘤的免疫介导反应?
World Neurosurg. 2021 Jan;145:172-177. doi: 10.1016/j.wneu.2020.09.064. Epub 2020 Sep 17.
4
Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment.原发性中枢神经系统淋巴瘤:分子发病机制与治疗进展
Transl Oncol. 2019 Mar;12(3):523-538. doi: 10.1016/j.tranon.2018.11.011. Epub 2019 Jan 4.
5
Primary central nervous system lymphoma: essential points in diagnosis and management.原发性中枢神经系统淋巴瘤:诊断与管理要点
Med Oncol. 2017 Apr;34(4):61. doi: 10.1007/s12032-017-0920-7. Epub 2017 Mar 17.
6
Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination.诊断警示:激素治疗后的恶性中枢神经系统淋巴瘤,类似于自身免疫性炎症性脱髓鞘。
Brain Pathol. 2018 Mar;28(2):225-233. doi: 10.1111/bpa.12496. Epub 2017 Apr 6.
7
The Multiple Faces of Nervous System Lymphoma. Atypical Magnetic Resonance Imaging Features and Contribution of the Advanced Imaging.神经系统淋巴瘤的多面性。非典型磁共振成像特征及先进成像技术的作用。
Curr Probl Diagn Radiol. 2017 Mar-Apr;46(2):136-145. doi: 10.1067/j.cpradiol.2016.04.004. Epub 2016 Apr 27.
8
Neuroinflammation Preceding and Accompanying Primary Central Nervous System Lymphoma: Case Study and Literature Review.原发性中枢神经系统淋巴瘤之前及伴随的神经炎症:病例研究与文献综述
World Neurosurg. 2016 Apr;88:692.e1-692.e8. doi: 10.1016/j.wneu.2015.11.099. Epub 2015 Dec 24.
9
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.视神经脊髓炎谱系障碍国际共识诊断标准
Neurology. 2015 Jul 14;85(2):177-89. doi: 10.1212/WNL.0000000000001729. Epub 2015 Jun 19.
10
Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas.霍奇金淋巴瘤和非霍奇金淋巴瘤中的副肿瘤性神经综合征
Blood. 2014 May 22;123(21):3230-8. doi: 10.1182/blood-2014-03-537506. Epub 2014 Apr 4.

原发中枢神经系统淋巴瘤之前的纵向广泛横贯性脊髓炎:脊髓哨兵神经炎症。

Longitudinally extensive transverse myelitis preceding primary central nervous system lymphoma: Spinal sentinel neuroinflammation.

机构信息

Neurology Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, İstanbul, Turkey.

Hematology Department, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, İstanbul, Turkey.

出版信息

J Spinal Cord Med. 2023 May;46(3):521-524. doi: 10.1080/10790268.2022.2087137. Epub 2022 Jun 27.

DOI:10.1080/10790268.2022.2087137
PMID:35758941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10116916/
Abstract

65-year-old female diagnosed with longitudinally extensive transverse myelitis. She had excellent response to immunotherapy despite her atypical features, and her spinal lesion was fully recovered in the second month of the treatment. Nine months after, she was diagnosed with primary cerebral central nervous system lymphoma while there was no recurrence of the spinal cord lesion as her most recent follow-up visit being 2 years after the LETM. Spinal sentinel neuroinflammation preceding primary central nervous system lymphoma might represent a valuable etiology in the differentials of LETM, as illustrated here.

摘要

一位 65 岁女性被诊断为长节段横贯性脊髓炎。尽管她的症状不典型,但她对免疫疗法反应良好,治疗的第二个月时她的脊髓病变已完全恢复。9 个月后,她被诊断为原发性大脑中枢神经系统淋巴瘤,而她最近的随访是在 LETM 后 2 年,此时她的脊髓病变没有复发。原发性中枢神经系统淋巴瘤之前的脊髓哨兵神经炎症可能代表 LETM 鉴别诊断中的一个有价值的病因,如下所示。