The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.
作者信息
Lyssenko Nicholas N, Shi Xinghua, Praticò Domenico
机构信息
Alzheimer's Center at Temple, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Department of Computer & Information Sciences, College of Science and Technology, Temple University, Philadelphia, PA, USA.
出版信息
Acta Neuropathol. 2022 Sep;144(3):585-587. doi: 10.1007/s00401-022-02459-8. Epub 2022 Jun 27.
Abstract
摘要
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The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.ABCA7启动子和5'区域中的阿尔茨海默病全基因组关联研究风险等位基因会降低ABCA7的表达。
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本文引用的文献
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rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls.rs4147929变异次要等位基因增加ABCA7基因表达，且与对照组相比，ABCA7在阿尔茨海默病患者中表现出基因表达增加。
Acta Neuropathol. 2020 May;139(5):937-940. doi: 10.1007/s00401-020-02135-9. Epub 2020 Feb 29.
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Curr Med Chem. 2019;26(7):1079-1112. doi: 10.2174/0929867324666170920141707.
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