Schneider D A, Schertel E R, Green J F
Respir Physiol. 1987 Mar;67(3):347-56. doi: 10.1016/0034-5687(87)90064-8.
The pattern of breathing induced by increases in end-expired lung volume (EEVL) was determined in 9 anesthetized dogs. The pulmonary and systemic circulations were separately pump-perfused and the lungs were ventilated with a servo-ventilator actuated from the phrenic neurogram. EEVL was increased as a continuous ramp by slowly raising end-expired transpulmonary pressure from 1.5 to 12 cm H2O. Tidal volume (VT), inspiratory time (TI), and expiratory time (TE) were measured at vagal temperatures of 39 degrees C and 7 degrees C and following vagotomy. At a vagal temperature of 39 degrees C, increasing EEVL produced significant reductions in VT and TI while greatly prolonging TE. Vagal cooling to 7 degrees C, substantially altered the reflex response to increased EEVL. At 7 degrees C, VT decreased as EEVL increased, but the reduction was not so pronounced as at 39 degrees C. In addition, both TI and TE shortened. Increasing EEVL following vagotomy had no consistent effects on breathing pattern. We conclude that increasing EEVL stimulates tachypneic promoting pulmonary afferent nerves, most likely pulmonary C-fibers, but at normal vagal temperature their effect is masked by the stronger reflex inhibition of slowly adapting pulmonary stretch receptors.
在9只麻醉犬中确定了由终末呼气肺容积（EEVL）增加所诱发的呼吸模式。肺循环和体循环分别用泵灌注，肺通过由膈神经电图驱动的伺服呼吸机进行通气。通过将终末呼气跨肺压从1.5厘米水柱缓慢升至12厘米水柱，使EEVL以连续斜坡的形式增加。在39℃和7℃的迷走神经温度下以及迷走神经切断术后，测量潮气量（VT）、吸气时间（TI）和呼气时间（TE）。在39℃的迷走神经温度下，增加EEVL会使VT和TI显著降低，同时大大延长TE。将迷走神经冷却至7℃，显著改变了对EEVL增加的反射反应。在7℃时，随着EEVL增加VT降低，但降低程度不如在39℃时明显。此外，TI和TE均缩短。迷走神经切断术后增加EEVL对呼吸模式没有一致的影响。我们得出结论，增加EEVL会刺激促呼吸增快的肺传入神经，最有可能是肺C纤维，但在正常迷走神经温度下，它们的作用被来自慢适应性肺牵张感受器的更强反射抑制所掩盖。
