Department of Cardiology, Huanggang Central Hospital, Huanggang, China.
Huanggang Institute of Translation Medicine, Huanggang, China.
Am J Physiol Cell Physiol. 2022 Aug 1;323(2):C630-C639. doi: 10.1152/ajpcell.00123.2022. Epub 2022 Jun 27.
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease due to the global pandemic of metabolic diseases. Dysregulation of hepatic lipid metabolism plays a central role in the initiation and progression of NAFLD. With the advancement of lipidomics, an increasing number of lipid species and underlying mechanisms associating hepatic lipid components have been revealed. Therefore, the focus of this review is to highlight the links between hepatic lipid species and their mechanisms mediating the pathogenesis of NAFLD. We first summarized the interplay between NAFLD and hepatic lipid disturbances. Next, we focused on reviewing the role of saturated fatty acids, cholesterol, oxidized phospholipids, and their respective intermediates in the pathogenesis of NAFLD. The mechanisms by which monounsaturated fatty acids and other pro-resolving mediators exert protective effects are also addressed. Finally, we further discussed the implication of different analysis approaches in lipidomics. Evolving insights into the pathophysiology of NAFLD will provide the opportunity for drug development.
非酒精性脂肪性肝病（NAFLD）已成为最常见的肝脏疾病，这与代谢性疾病的全球流行有关。肝脂质代谢失调在 NAFLD 的发生和进展中起着核心作用。随着脂质组学的发展，越来越多的脂质种类及其与肝脂质成分相关的潜在机制被揭示出来。因此，本综述的重点是强调肝脂质种类及其介导 NAFLD 发病机制的机制之间的联系。我们首先总结了 NAFLD 与肝脂质紊乱之间的相互作用。接下来，我们重点回顾了饱和脂肪酸、胆固醇、氧化磷脂及其各自中间产物在 NAFLD 发病机制中的作用。单不饱和脂肪酸和其他促解决介质发挥保护作用的机制也得到了阐述。最后，我们进一步讨论了不同分析方法在脂质组学中的应用。对 NAFLD 病理生理学的不断深入了解将为药物开发提供机会。
