Meghan F. Haas, DO, FACOI, Jessica Latchman, ARNP, Ann M. Guastella, ARNP, David S. Craig, PharmD, and Young D. Chang, MD, are with theDepartment of Supportive Care, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
J Pain Palliat Care Pharmacother. 2022 Sep;36(3):194-199. doi: 10.1080/15360288.2022.2081754. Epub 2022 Jun 27.
Here, we describe a case of a patient with multiple myeloma who reported symptoms of lucid dreams. This patient was taking methadone for neoplasm related pain. The patient was also taking pregabalin which was initially started at dosing of 50 mg taken orally three times a day. Five days after initiation of pregabalin, the dosing was increased to 100 mg taken orally three times daily. The patient developed lucid dreams during a hospital stay and methadone was initially thought to be the cause of her lucid dreams. Methadone dosing was decreased with no success, and her lucid dreams persisted. On the patient's thirteenth day of hospital admission, the pregabalin dose was decreased from 100 mg three times a day to 75 mg twice daily. Five days later, the pregabalin was decreased from 75 mg twice daily to 50 mg twice daily. Pregabalin was continued for five more days and then discontinued. Resolution of the lucid dreams occurred following discontinuation of pregabalin. To our knowledge, this is the first reported case of an association between pregabalin and lucid dreams. Given that pregabalin is a widely used medication, we found this case to be relevant to describe this unique presentation.
在这里，我们描述了一例多发性骨髓瘤患者出现清醒梦症状的病例。该患者因肿瘤相关疼痛而服用美沙酮。该患者还服用普瑞巴林，初始剂量为 50mg，每日口服 3 次。普瑞巴林开始使用 5 天后，剂量增加至 100mg，每日口服 3 次。该患者在住院期间出现清醒梦，最初认为美沙酮是导致她出现清醒梦的原因。减少美沙酮的剂量并没有成功，她的清醒梦仍在继续。在患者住院的第 13 天，将普瑞巴林的剂量从每日 3 次 100mg 减少到每日 2 次 75mg。5 天后，将普瑞巴林的剂量从每日 2 次 75mg 减少到每日 2 次 50mg。继续使用普瑞巴林 5 天，然后停药。在停用普瑞巴林后，清醒梦得到缓解。据我们所知，这是首例报道的普瑞巴林与清醒梦之间关联的病例。鉴于普瑞巴林是一种广泛使用的药物，我们认为该病例与描述这种独特表现有关。
