The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.
Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Curr Eye Res. 2022 Sep;47(9):1288-1293. doi: 10.1080/02713683.2022.2093383. Epub 2022 Jul 4.
To evaluate seasonal and environmental variations on the incidence and outcomes of postinjection endophthalmitis.
A single-center, retrospective cohort study was conducted including all patients diagnosed with post-injection endophthalmitis between 2013-2018. Associations between climate variables and endophthalmitis incidence were evaluated.
Of 423,297 injections administered, seasonal distribution in spring, summer, autumn, and winter was 26%, 27%, 25%, and 22%, respectively. Of 171 cases of endophthalmitis identified, seasonal distribution over the spring, summer, autumn, and fall was 25%, 23%, 26%, and 26%, respectively. Endophthalmitis incidence was not correlated with monthly precipitation ( = 0.45), monthly snowfall ( = 0.49), or monthly temperature ( = 0.65). Worse visual outcomes at initial endophthalmitis presentation were correlated with increased precipitation level ( = 0.025) but were not correlated with snowfall level ( = 0.228) or mean monthly temperature ( = 0.132). Although there were no seasonal variations of visual acuity at endophthalmitis presentation ( = 0.894), odds of final visual acuity returning to within two lines of pre-endophthalmitis visual acuity were worse among patients with endophthalmitis diagnosed in the spring (OR, 0.041; = 0.016).
In contrast to previous work on postcataract endophthalmitis, seasonal and weather factors were not associated with post-injection endophthalmitis risk or bacterial species isolated. Visual outcomes at initial endophthalmitis presentation were correlated with precipitation, and worse visual outcomes were seen in patients who developed endophthalmitis in the spring.
评估注射后眼内炎发病和结局的季节性和环境变化。
对 2013-2018 年间诊断为注射后眼内炎的所有患者进行了一项单中心、回顾性队列研究。评估了气候变量与眼内炎发病率之间的关系。
在 423297 次注射中，春季、夏季、秋季和冬季的季节分布分别为 26%、27%、25%和 22%。在 171 例眼内炎病例中，春季、夏季、秋季和冬季的季节分布分别为 25%、23%、26%和 26%。眼内炎发病率与每月降水量（ = 0.45）、每月降雪量（ = 0.49）或月平均温度（ = 0.65）无关。初始眼内炎表现时较差的视力结局与降水水平增加相关（ = 0.025），但与降雪水平（ = 0.228）或月平均温度（ = 0.132）无关。尽管初始眼内炎表现时的视力没有季节性变化（ = 0.894），但在春季诊断为眼内炎的患者中，最终视力恢复到眼内炎前视力的两线以内的可能性较低（OR，0.041； = 0.016）。
与先前关于白内障术后眼内炎的研究结果不同，季节性和天气因素与注射后眼内炎的风险或分离出的细菌种类无关。初始眼内炎表现时的视力结果与降水有关，在春季发生眼内炎的患者中，视力结果较差。
