General Surgery Department, James Cook University Hospital, England.
General Surgery Department, Faculty of Medicine, Assiut University, Egypt.
Am Surg. 2023 Nov;89(11):4811-4816. doi: 10.1177/00031348221111512. Epub 2022 Jun 27.
Primary thyroid lymphoma (PTL) is a rare malignancy accounting for about 5% of all thyroid malignancies and less than 2% of extra-nodal lymphomas. Diffuse B-cell lymphoma is the most common pathological subtype of PTL.
This is a retrospective review of all patients diagnosed with thyroid lymphoma in our hospital during the period from 2011 to 2021. All patients had clinical, radiological, and pathological evaluation. We have followed up these patients since diagnosis till now.
Eight patients were included in our review. Four patients were males and four were females. Mean age at diagnosis was 63 ± 32 years of age. Diagnosis was confirmed only with tissue histology. Six patients had stage IIE disease and two had stage IVE disease. Four patients had disease related mortality. Of the other four patients, two had chemotherapy (RCHOP) and one had local radiotherapy; all achieved complete remission, and the last one had hemithyroidectomy to relieve airway compression and still under treatment.
Primary thyroid lymphoma is rare malignancy of the thyroid gland. Advanced stage and age at the time of diagnosis, the presence of compression manifestations, large tumor mass, and presence of distant metastasis, all are poor prognostic criteria. Our knowledge of the disease pathology, diagnosis, and management is still limited and more research studies are required.
原发性甲状腺淋巴瘤（PTL）是一种罕见的恶性肿瘤，约占所有甲状腺恶性肿瘤的 5%，不到结外淋巴瘤的 2%。弥漫性 B 细胞淋巴瘤是 PTL 最常见的病理亚型。
这是对 2011 年至 2021 年期间在我院诊断为甲状腺淋巴瘤的所有患者进行的回顾性研究。所有患者均进行了临床、影像学和病理学评估。自诊断以来，我们一直对这些患者进行随访。
共有 8 例患者纳入本研究。4 例为男性，4 例为女性。诊断时的平均年龄为 63 ± 32 岁。仅通过组织病理学确诊。6 例患者为 IIE 期疾病，2 例为 IVE 期疾病。4 例患者有疾病相关死亡。在其他 4 例患者中，2 例接受了化疗（RCHOP），1 例接受了局部放疗；所有患者均达到完全缓解，最后 1 例因缓解气道压迫行甲状腺半切除术，仍在治疗中。
原发性甲状腺淋巴瘤是一种罕见的甲状腺恶性肿瘤。晚期和诊断时的年龄、存在压迫表现、大肿瘤体积和存在远处转移，均是预后不良的标准。我们对该病的病理、诊断和治疗的认识仍然有限，需要进行更多的研究。
