The effect of peripheral arterial disease and intermittent claudication on gait regularity and symmetry.

Peripheral arterial disease (PAD) affects 20-30% of older adults and is associated with intermittent claudication (IC), which is walking-induced pain. This study compared the regularity and symmetry of gait between healthy older adults and adults with PAD, and between IC and non-IC conditions in the PAD group. Eighteen control (70.7 ± 6.3 years) and 11 PAD participants (67.0 ± 10.1 years) walked overground at a continuous, self-selected speed. A waist-mounted accelerometer determined step time, stride time, gait speed and mediolateral (ML), vertical (V) and anteroposterior (AP) gait regularity (step/stride) and symmetry. Correlations between ankle-brachial index (ABI) scores and PAD gait regularity/symmetry were also investigated. PAD step and stride times were greater (p < 0.01), while gait speed, ML and AP step regularity and ML and V stride regularity were significantly less than the controls (p < 0.05). There were no significant differences in gait symmetry. Within the PAD group, post-IC step/stride time and speed increased and decreased, respectively, (p < 0.05), while post-IC step and stride regularity were significantly less in all three directions (p < 0.01). Similarly, ML and V post-IC gait asymmetry increased significantly (p < 0.05). ABI was significantly correlated with pre-and post-IC vertical stride regularity (p < 0.01), and with pre- and post-IC ML gait symmetry (p < 0.05). The results demonstrate that gait regularity decreases as a result of PAD and IC. The association between gait regularity/symmetry and ABI should be investigated further, as it may have clinical application to the assessment of PAD severity.